Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
Chemistry
Ligand Efficiency Plot
Pathways
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
RNAi
Mutations
Germline Genetics

IFT22 (Q9H7X7) - Overview - Molecular Target Synopsis

Protein


IFT22, Intraflagellar transport protein 22 homolog
UniProt Q9H7X7

Also Known as IFT22_HUMAN, IFT22, RABL5

Small GTPase-like component of the intraflagellar transport (IFT) complex B. Component of the IFT complex B, at least composed of IFT20, IFT22, HSPB11/IFT25, IFT27, IFT46, IFT52, TRAF3IP1/IFT54, IFT57, IFT74, IFT80, IFT81, and IFT88. Interacts with IFT88.

Isoforms / Transcripts (Protein Coding)


Sub-cellular localization


UniProt: IFT22 is active in the following subcellular-locations: cell projection, cilium.
GO terms: IFT22 is active in the following subcellular-locations: centrosome, ciliary tip, cilium, intraciliary transport particle B.



UniProt
GO terms

Gene Copy Number Variation


In COSMIC - Cell Lines Project IFT22 has gain in 5 cell-lines, loss in 1 cell-lines and no signal in 999 cell-lines. (see details)

Gene Expression


In NCI60, the highest expressing cell lines are:

In Array Express (RNA-seq of 675 commonly used human cancer cell lines), the highest expressing cell lines are: EBC-1, OVSAHO, PE/CA-PJ15

In Array Express (RNA-seq of long poly adenylated RNA and long non poly adenylated RNA from ENCODE cell lines), the highest expressing cell lines are: BJ, HeLa-S3, A549

(see details)

3D Structures


At greater than 35% identity similarity to IFT22 there are:
2 structures (4 chains) solved
2 are solved in complex with at least one small molecule ligand



(see details)
Molecular Target 3D Synopsis