Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
Chemistry
Ligand Efficiency Plot
Pathways
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
RNAi
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Germline Genetics

NAA60 (Q9H7X0) - Overview - Molecular Target Synopsis

Protein


NAA60, N-alpha-acetyltransferase 60
Enzyme Classification 2.3.1.259
UniProt Q9H7X0

Also Known as NAA60_HUMAN, NAA60, HAT4, NAT15

N-alpha-acetyltransferase that specifically mediates the acetylation of N-terminal residues of the transmembrane proteins, with a strong preference for N-termini facing the cytosol (PubMed:25732826). Displays N-terminal acetyltransferase activity towards a range of N-terminal sequences including those starting with Met-Lys, Met-Val, Met-Ala and Met-Met (PubMed:21750686, PubMed:25732826, PubMed:27550639, PubMed:27320834). Required for normal chromosomal segregation during anaphase (PubMed:21750686). May also show histone acetyltransferase activity; such results are however unclear in vivo and would require additional experimental evidences (PubMed:21981917). Monomer and homodimer; monomer in presence of substrate and homodimer in its absence (PubMed:27320834).

5HH0
CRYSTAL STRUCTURE OF HUMAN NAA60 IN COMPLEX WITH COA
RCSB/PDB
Inspect Structure
See all 3D Structures for NAA60

Isoforms / Transcripts (Protein Coding)


Sub-cellular localization


UniProt: NAA60 is active in the following subcellular-locations: golgi apparatus membrane.
GO terms: NAA60 is active in the following subcellular-locations: Golgi membrane.



UniProt
GO terms

Gene Copy Number Variation


In COSMIC - Cell Lines Project NAA60 has gain in 0 cell-lines, loss in 1 cell-lines and no signal in 1004 cell-lines. (see details)

Gene Expression


In NCI60, the highest expressing cell lines are:

In Array Express (RNA-seq of 675 commonly used human cancer cell lines), the highest expressing cell lines are: SK-N-FI, NCI-H1651, MDA-MB-361

In Array Express (RNA-seq of long poly adenylated RNA and long non poly adenylated RNA from ENCODE cell lines), the highest expressing cell lines are: SK-N-SH, A549, NHLF

(see details)

3D Structures


For NAA60 there are:
5 structures (9 chains) solved
4 are solved in complex with at least one small molecule ligand



(see details)
Molecular Target 3D Synopsis