Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
Chemistry
Ligand Efficiency Plot
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MVB12B (Q9H7P6) - Overview - Molecular Target Synopsis

Protein


MVB12B, Multivesicular body subunit 12B
UniProt Q9H7P6

Also Known as MB12B_HUMAN, MVB12B, C9orf28, FAM125B

Component of the ESCRT-I complex, a regulator of vesicular trafficking process. Required for the sorting of endocytic ubiquitinated cargos into multivesicular bodies. Component of the ESCRT-I complex (endosomal sorting complex required for transport I) which consists of TSG101, VPS28, a VPS37 protein (VPS37A to -D) and MVB12A or MVB12B in a 1:1:1:1 stoichiometry. Interacts with TSG101; the association appears to be mediated by the TSG101-VPS37 binary subcomplex. Interacts with VPS28. Interacts with VPS37B; the association appears to be mediated by the TSG101-VPS37 binary subcomplex. Interacts with VPS37C; the association appears to be mediated by the TSG101-VPS37 binary subcomplex.

3TOW
CRYSTAL STRUCTURE OF THE MABP DOMAIN OF MVB12B OF HUMAN ESCRT-I COMPLEX
RCSB/PDB
Inspect Structure
See all 3D Structures for MVB12B

Isoforms / Transcripts (Protein Coding)


Sub-cellular localization


UniProt: MVB12B is active in the following subcellular-locations: endosome, late endosome membrane.
GO terms: MVB12B is active in the following subcellular-locations: cytosol, early endosome, endosome membrane, ESCRT I complex, extracellular exosome, late endosome, late endosome membrane, nucleus, plasma membrane, vesicle.



UniProt
GO terms

Gene Copy Number Variation


In COSMIC - Cell Lines Project MVB12B has gain in 0 cell-lines, loss in 1 cell-lines and no signal in 1004 cell-lines. (see details)

Gene Expression


In NCI60, the highest expressing cell lines are:

In Array Express (RNA-seq of 675 commonly used human cancer cell lines), the highest expressing cell lines are: SCLC-22H, COLO 205, NCI-H187

In Array Express (RNA-seq of long poly adenylated RNA and long non poly adenylated RNA from ENCODE cell lines), the highest expressing cell lines are: NHLF, SK-N-SH, HMEC

(see details)

3D Structures


For MVB12B there are:
1 structures (1 chains) solved
0 are solved in complex with at least one small molecule ligand



(see details)
Molecular Target 3D Synopsis