Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
Chemistry
Ligand Efficiency Plot
Pathways
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
RNAi
Mutations
Germline Genetics

PEAK1 (Q9H792) - Overview - Molecular Target Synopsis

Protein


PEAK1, Inactive tyrosine-protein kinase PEAK1
UniProt Q9H792

Also Known as PEAK1_HUMAN, PEAK1, KIAA2002

Probable catalytically inactive kinase. Scaffolding protein that regulates the cytoskeleton to control cell spreading and migration by modulating focal adhesion dynamics (PubMed:23105102, PubMed:20534451). Acts as a scaffold for mediating EGFR signaling (PubMed:23846654). Homodimer (PubMed:29212708). Interacts with BCAR1 and CRK (PubMed:20534451). Interacts with PRAG1 (PubMed:29079850). Interacts (when phosphorylated at Tyr-1188) with SHC1 (via PID domain) (PubMed:23846654). Found in a complex with PPP1CA, PPP1CC, SHC1 and PEAK1.

6BHC
CRYSTAL STRUCTURE OF PSEDUOKINASE PEAK1 (SUGEN KINASE 269)
RCSB/PDB
Inspect Structure
See all 3D Structures for PEAK1

Isoforms / Transcripts (Protein Coding)


Sub-cellular localization


UniProt: PEAK1 is active in the following subcellular-locations: cell junction, cytoplasm, cytoskeleton, focal adhesion.
GO terms: PEAK1 is active in the following subcellular-locations: actin cytoskeleton, cytoplasm, focal adhesion.



UniProt
GO terms

Gene Copy Number Variation


In COSMIC - Cell Lines Project PEAK1 has gain in 0 cell-lines, loss in 2 cell-lines and no signal in 1003 cell-lines. (see details)

Gene Expression


In NCI60, the highest expressing cell lines are:

In Array Express (RNA-seq of 675 commonly used human cancer cell lines), the highest expressing cell lines are: JL-1, NCI-H196, G22

In Array Express (RNA-seq of long poly adenylated RNA and long non poly adenylated RNA from ENCODE cell lines), the highest expressing cell lines are: NHLF, SK-N-SH, BJ

(see details)

RNA Interference


PEAK1 was reported in the following RNAI studies:

Cell - Large Scale Profiling of Kinase Dependencies in Cancer Cell Lines, the highest RNAi cell lines are: MDAMB453, CAMA1. (see details)

3D Structures


For PEAK1 there are:
1 structures (1 chains) solved
0 are solved in complex with at least one small molecule ligand



(see details)
Molecular Target 3D Synopsis