Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
Chemistry
Ligand Efficiency Plot
Pathways
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
RNAi
Mutations
Germline Genetics

LDAH (Q9H6V9) - Overview - Molecular Target Synopsis

Protein


LDAH, Lipid droplet-associated hydrolase
Enzyme Classification 3.1.1.-
UniProt Q9H6V9

Also Known as LDAH_HUMAN, LDAH, C2orf43

Serine lipid hydrolase associated with lipid droplets. Highly expressed in macrophage-rich areas in atherosclerotic lesions, suggesting that it could promote cholesterol ester turnover in macrophages.

Isoforms / Transcripts (Protein Coding)


Sub-cellular localization


UniProt: LDAH is active in the following subcellular-locations: endoplasmic reticulum, lipid droplet.
GO terms: LDAH is active in the following subcellular-locations: endoplasmic reticulum, lipid droplet.



UniProt
GO terms

Gene Copy Number Variation


In COSMIC - Cell Lines Project LDAH has gain in 4 cell-lines, loss in 0 cell-lines and no signal in 1001 cell-lines. (see details)

Gene Expression


In NCI60, the highest expressing cell lines are:

In Array Express (RNA-seq of 675 commonly used human cancer cell lines), the highest expressing cell lines are: SK-N-FI, EBC-1, NCI-H1581

In Array Express (RNA-seq of long poly adenylated RNA and long non poly adenylated RNA from ENCODE cell lines), the highest expressing cell lines are: NHLF, HSMM, K562

(see details)