Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
Chemistry
Ligand Efficiency Plot
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Interaction Network
Gene Expression
Gene Copy Number Variation
RNAi
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Germline Genetics

RPAP3 (Q9H6T3) - Druggability - Molecular Target Synopsis

Chain-based assessment (last updated 23/07/2019)
Structural Druggability Help: Help

Chain-based assessment (last updated 23/07/2019)


Chains assessed14
Chains with at least one site assessed as druggable using the strict criteria1
Chains with at least one site assessed as druggable using the relaxed criteria8


		
PDB Chain Protein Name Druggable Relaxed Druggable Strict Details
6FM8_A RNA polymerase II-associated protein 3 No No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.03 65 18.7 No No
2 empty 1.97 66.3 21.7 No No
3 empty 2.15 60 5.5 No No
4 empty 2.17 56.5 8 No No
5 empty 2.94 63.6 5 No No
6FD7_A RNA polymerase II-associated protein 3 No No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.15 66.7 22.8 No No
2 empty 2.42 57.1 16.8 No No
3 empty 2.11 40.8 7.7 No No
4 empty 2.44 59.4 8.3 No No
5 empty 2.46 66.9 5.8 No No
6 empty 2.47 62.7 7 No No
7 empty 2.04 69.9 6.2 No No
8 empty 2.51 53.9 8.6 No No
9 empty 2.4 66.9 7.6 No No
10 empty 2.04 47.2 6.7 No No
6FDT_A RNA polymerase II-associated protein 3 Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.12 68.6 23.1 No No
2 empty 2.41 52.9 17.2 No No
3 empty 2.05 68.2 8.6 No No
4 empty 2.5 61.1 14.2 No No
5 empty 2.19 61.7 9.5 No No
6 empty 2.57 61.9 6.3 No No
7 empty 3 64.8 6.4 No No
8 empty 1.97 64.9 6.7 No No
9 empty 1.89 84.6 5.3 Yes No
10 empty 2.92 63 9.5 No No
4CGV_B RNA polymerase II-associated protein 3 No No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.1 66.6 19.2 No No
2 empty 2.23 65 13.1 No No
3 empty 2.3 76.4 6.8 No No
4 empty 2.06 55.1 11.3 No No
5 empty 2.67 61.3 7.4 No No
6 empty 3.1 71.1 4.1 No No
7 empty 2.63 52.3 6.9 No No
8 empty 1.49 62.8 6.9 No No
9 empty 2.81 50.6 6.1 No No
10 empty 2.91 61.7 5.3 No No
6FDP_A RNA polymerase II-associated protein 3 Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.14 64.3 33.5 Yes No
2 empty 2.09 59 14 No No
3 empty 2.41 57.3 11.4 No No
4 empty 2.26 59.5 12 No No
5 empty 2.01 62 10.6 No No
6 empty 2.72 71.3 6.6 No No
7 empty 2.8 62.4 7.8 No No
8 empty 2.45 61.8 6.3 No No
9 empty 2.99 68.8 5.8 No No
10 empty 2.33 62.9 5.6 No No
6GXZ_C RNA polymerase II-associated protein 3 Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.05 59.1 25 Yes No
2 empty 1.96 65.5 29.3 No No
3 empty 1.74 51.5 17.3 No No
4 empty 2.13 55.4 15.8 No No
5 empty 1.78 40.4 15.1 No No
6 empty 2.44 60.7 12.5 No No
7 empty 2.04 64.1 10.4 No No
8 empty 1.9 66.4 8 No No
9 empty 2.66 60.3 7.4 No No
10 empty 1.6 44.8 11.3 No No
4CGW_B RNA polymerase II-associated protein 3 No No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.03 53.8 14.4 No No
2 empty 2.97 66.5 9.4 No No
3 empty 1.97 69.1 8.1 No No
4 empty 1.53 72 7.6 No No
5 empty 2.11 67.5 10.9 No No
6 empty 2.69 64.5 8.8 No No
7 empty 2.85 60.2 8.6 No No
8 empty 2.46 55.7 8 No No
9 empty 1.64 57.1 7.1 No No
10 empty 2.7 64.6 7.7 No No
6FO1_G RNA polymerase II-associated protein 3 Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.22 70.7 20.1 No No
2 empty 1.78 79.1 17.7 Yes Yes
3 empty 2.37 68.3 16.6 No No
4 empty 2.56 70.5 12.1 No No
5 empty 2.22 69.2 11.4 No No
6 empty 2.51 66.2 14.7 No No
7 empty 2.21 61.2 11.9 No No
8 empty 2.01 75.9 10.7 No No
9 empty 2.46 66.5 10.7 No No
10 empty 2.53 61.8 11.7 No No
4CGW_A RNA polymerase II-associated protein 3 No No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 1.59 67.3 12.5 No No
2 empty 2.06 52.4 14.1 No No
3 empty 3.03 71.1 8.3 No No
4 empty 1.97 70 9.7 No No
5 empty 1.94 64.8 10.8 No No
6 empty 1.86 54.7 10.8 No No
7 empty 2.98 58.5 7.8 No No
8 empty 2.11 64.8 5.4 No No
9 empty 2.33 60.9 6.4 No No
10 empty 2.77 73.5 4.7 No No
6GXZ_A RNA polymerase II-associated protein 3 Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 1.98 62.1 25.8 Yes No
2 empty 1.91 54.5 20.4 No No
3 empty 1.94 69.9 10.6 No No
4 empty 2 66 14.6 No No
5 empty 1.7 65.8 10.3 No No
6 empty 2.04 56.5 12.9 No No
7 empty 2.17 64.3 9.7 No No
8 empty 2.63 63 10.2 No No
9 empty 2.38 62.3 9.9 No No
10 empty 3.21 69.2 0 No No
6EZ4_A RNA polymerase II-associated protein 3 Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 1.88 58.4 25.2 Yes No
2 empty 2.6 56.9 18.7 No No
3 empty 2.46 64.8 15.1 No No
4 empty 2.31 72.6 8.6 No No
5 empty 2.33 61.1 12.8 No No
6 empty 2.18 67 10.3 No No
7 empty 2.82 72.7 9.9 No No
8 empty 1.98 60.7 11.5 No No
9 empty 2.68 66.2 11.1 No No
10 empty 2.46 59.9 11.6 No No
4CGV_A RNA polymerase II-associated protein 3 No No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 1.77 66.6 18.6 No No
2 empty 2.5 59.7 12.7 No No
3 empty 2.3 63.7 9.3 No No
4 empty 1.82 75.5 5.9 No No
5 empty 2.39 81.7 0 No No
6 empty 2.45 46.4 5.8 No No
7 empty 2.79 74 0 No No
8 empty 2.88 62.7 5.9 No No
4CGV_C RNA polymerase II-associated protein 3 Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.06 64.9 26.1 Yes No
2 empty 2.37 52 14.4 No No
3 empty 2.31 67.4 11.1 No No
4 empty 2.54 61.6 8.3 No No
5 empty 2.27 60 9.9 No No
6 empty 2.33 73.3 6.5 No No
7 empty 2.86 46.1 7.3 No No
8 empty 2.58 58.8 6.6 No No
9 empty 2.42 60.8 7.1 No No
10 empty 2.77 59.5 6.1 No No
4CGV_D RNA polymerase II-associated protein 3 Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 1.88 63.2 24.4 Yes No
2 empty 2.49 57 13.9 No No
3 empty 2.82 57.7 5.9 No No
4 empty .67 70.5 4.7 No No
5 empty 2.43 55.7 5.3 No No
Ligand-based Druggability Score: -3
Ligand-based Druggability Score Percentile: 59%
Ligand-based Druggability Help: Help




		
Number of proteins in the network : 13346


RPAP3 is involved in 17 interactions in the network.


Druggability
Overall Druggability Percentile: 76.99
Druggability for Cancer Therapeutics: 73.19
Druggability for Other Therapeutics: 56.61
Cancer-Associated
Cancer-associated percentile : 71.20
Network Articulation Point
Is RPAP3 critical for communication in the network?


Detailed Graph Legend:Help