Molecular Target Synopsis
Domains and Structures
Drugs and Clinical Candidates
Ligand Efficiency Plot
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
Germline Genetics

RPAP3 (Q9H6T3) - Overview - Molecular Target Synopsis


RPAP3, RNA polymerase II-associated protein 3
UniProt Q9H6T3

Also Known as RPAP3_HUMAN, RPAP3

Forms an interface between the RNA polymerase II enzyme and chaperone/scaffolding protein, suggesting that it is required to connect RNA polymerase II to regulators of protein complex formation. Tightly associated with the RNA polymerase II complex (PubMed:17643375). Component of the R2TP complex composed at least of PIHD1, RUVBL1, RUVBL2 and RPAP3 (PubMed:20864032). Interacts with PIH1D1 (PubMed:21078300).

Inspect Structure
See all 3D Structures for RPAP3

Isoforms / Transcripts (Protein Coding)

Sub-cellular localization

GO terms: RPAP3 is active in the following subcellular-locations: cytosol, R2TP complex.

GO terms

Gene Copy Number Variation

In COSMIC - Cell Lines Project RPAP3 has gain in 8 cell-lines, loss in 0 cell-lines and no signal in 997 cell-lines. (see details)

Gene Expression

In NCI60, the highest expressing cell lines are: K_562, OVCAR_3, SF_268

In Array Express (RNA-seq of 675 commonly used human cancer cell lines), the highest expressing cell lines are: NCI-H1930, RL, ChaGo-K-1

In Array Express (RNA-seq of long poly adenylated RNA and long non poly adenylated RNA from ENCODE cell lines), the highest expressing cell lines are: NHLF, MCF-7, AG445

(see details)

3D Structures

For RPAP3 there are:
9 structures (14 chains) solved
0 are solved in complex with at least one small molecule ligand

(see details)
Molecular Target 3D Synopsis

Screening and Chemistry

RPAP3 has been screened with compounds ( bioactivities). (see details)