Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
Chemistry
Ligand Efficiency Plot
Pathways
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
RNAi
Mutations
Germline Genetics

RPAP3 (Q9H6T3) - Overview - Molecular Target Synopsis

Protein


RPAP3, RNA polymerase II-associated protein 3
UniProt Q9H6T3

Also Known as RPAP3_HUMAN, RPAP3

Forms an interface between the RNA polymerase II enzyme and chaperone/scaffolding protein, suggesting that it is required to connect RNA polymerase II to regulators of protein complex formation. Tightly associated with the RNA polymerase II complex (PubMed:17643375). Component of the R2TP complex composed at least of PIHD1, RUVBL1, RUVBL2 and RPAP3 (PubMed:20864032). Interacts with PIH1D1 (PubMed:21078300).

6FM8
RPAP3 C-TERMINUS
RCSB/PDB
Inspect Structure
See all 3D Structures for RPAP3

Isoforms / Transcripts (Protein Coding)


Sub-cellular localization


GO terms: RPAP3 is active in the following subcellular-locations: cytosol, R2TP complex.



UniProt
GO terms

Gene Copy Number Variation


In COSMIC - Cell Lines Project RPAP3 has gain in 8 cell-lines, loss in 0 cell-lines and no signal in 997 cell-lines. (see details)

Gene Expression


In NCI60, the highest expressing cell lines are: K_562, OVCAR_3, SF_268

In Array Express (RNA-seq of 675 commonly used human cancer cell lines), the highest expressing cell lines are: NCI-H1930, RL, ChaGo-K-1

In Array Express (RNA-seq of long poly adenylated RNA and long non poly adenylated RNA from ENCODE cell lines), the highest expressing cell lines are: NHLF, MCF-7, AG445

(see details)

3D Structures


For RPAP3 there are:
9 structures (14 chains) solved
0 are solved in complex with at least one small molecule ligand



(see details)
Molecular Target 3D Synopsis

Screening and Chemistry


RPAP3 has been screened with compounds ( bioactivities). (see details)