Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
Chemistry
Ligand Efficiency Plot
Pathways
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
RNAi
Mutations
Germline Genetics

YTHDC2 (Q9H6S0) - Overview - Molecular Target Synopsis

Protein


YTHDC2, 3'-5' RNA helicase YTHDC2
Enzyme Classification 3.6.4.13
UniProt Q9H6S0

Also Known as YTDC2_HUMAN, YTHDC2

3'-5' RNA helicase that plays a key role in the male and female germline by promoting transition from mitotic to meiotic divisions in stem cells (PubMed:26318451, PubMed:29033321). Specifically recognizes and binds N6-methyladenosine (m6A)-containing RNAs, a modification present at internal sites of mRNAs and some non-coding RNAs that plays a role in the efficiency of RNA processing and stability (PubMed:26318451, PubMed:29033321). Essential for ensuring a successful progression of the meiotic program in the germline by regulating the level of m6A-containing RNAs (By similarity). Acts by binding and promoting degradation of m6A-containing mRNAs: the 3'-5' RNA helicase activity is required for this process and RNA degradation may be mediated by XRN1 exoribonuclease (PubMed:29033321). Required for both spermatogenesis and oogenesis. Interacts with MEIOC; binds transcripts that regulate the mitotic cell cycle inhibiting progression into metaphase, thereby allowing meiotic prophase to proceed normally (By similarity). Interacts (via ANK repeats) with XRN1 (PubMed:29033321).

2YU6
SOLUTION STRUCTURE OF THE YTH DOMAIN IN YTH DOMAIN- CONTAINING PROTEIN 2
RCSB/PDB
Inspect Structure
See all 3D Structures for YTHDC2

Isoforms / Transcripts (Protein Coding)


Sub-cellular localization


UniProt: YTHDC2 is active in the following subcellular-locations: cytoplasm.
GO terms: YTHDC2 is active in the following subcellular-locations: cytoplasm, endoplasmic reticulum, nucleus, ribonucleoprotein granule.



UniProt
GO terms

Gene Copy Number Variation


In COSMIC - Cell Lines Project YTHDC2 has gain in 0 cell-lines, loss in 5 cell-lines and no signal in 1000 cell-lines. (see details)

Gene Expression


In NCI60, the highest expressing cell lines are: K_562, T47D, NCI_H460

In Array Express (RNA-seq of 675 commonly used human cancer cell lines), the highest expressing cell lines are: SK-N-FI, HCC1954, OV-90

In Array Express (RNA-seq of long poly adenylated RNA and long non poly adenylated RNA from ENCODE cell lines), the highest expressing cell lines are: MCF-7, GM12878, HSMM

(see details)

3D Structures


For YTHDC2 there are:
1 structures (1 chains) solved
0 are solved in complex with at least one small molecule ligand



(see details)
Molecular Target 3D Synopsis

Screening and Chemistry


YTHDC2 has been screened with compounds ( bioactivities). (see details)