Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
Chemistry
Ligand Efficiency Plot
Pathways
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
RNAi
Mutations
Germline Genetics

ACSS3 (Q9H6R3) - Overview - Molecular Target Synopsis

Protein


ACSS3, Acyl-CoA synthetase short-chain family member 3, mitochondrial
Enzyme Classification 6.2.1.1
UniProt Q9H6R3

Also Known as ACSS3_HUMAN, ACSS3

Activates acetate so that it can be used for lipid synthesis or for energy generation.

Isoforms / Transcripts (Protein Coding)


Sub-cellular localization


UniProt: ACSS3 is active in the following subcellular-locations: mitochondrion.
GO terms: ACSS3 is active in the following subcellular-locations: mitochondrial matrix.



UniProt
GO terms

Gene Copy Number Variation


In COSMIC - Cell Lines Project ACSS3 has gain in 4 cell-lines, loss in 0 cell-lines and no signal in 1000 cell-lines. (see details)

Gene Expression


In NCI60, the highest expressing cell lines are: MDA_N, SK_MEL_2, M14

In Array Express (RNA-seq of 675 commonly used human cancer cell lines), the highest expressing cell lines are: C3A, Hep G2, DMS 53

In Array Express (RNA-seq of long poly adenylated RNA and long non poly adenylated RNA from ENCODE cell lines), the highest expressing cell lines are: SK-N-SH, NHLF, HSMM

(see details)

3D Structures


At greater than 50% identity similarity to ACSS3 there are:
1 structures (1 chains) solved
1 are solved in complex with at least one small molecule ligand
1 are solved with an approved drug

ACSS3 is solved in complex with the approved drug(s):

AMP/ADENOSINE PHOSPHATE (5GXD_A).

(see details)
Molecular Target 3D Synopsis