Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
Chemistry
Ligand Efficiency Plot
Pathways
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
RNAi
Mutations
Germline Genetics

EPHX3 (Q9H6B9) - Overview - Molecular Target Synopsis

Protein


EPHX3, Epoxide hydrolase 3
Enzyme Classification 3.3.2.10
UniProt Q9H6B9

Also Known as EPHX3_HUMAN, EPHX3, ABHD9

Catalyzes the hydrolysis of epoxide-containing fatty acids. Active in vitro against epoxyeicosatrienoic acids (EETs) including 8,9-EET, 9,10-EET, 11,12-EET and 14,15-EET and leukotoxin.

Isoforms / Transcripts (Protein Coding)


Sub-cellular localization


UniProt: EPHX3 is active in the following subcellular-locations: microsome membrane.
GO terms: EPHX3 is active in the following subcellular-locations: endoplasmic reticulum, integral component of membrane, intracellular membrane-bounded organelle, membrane, organelle membrane.



UniProt
GO terms

Gene Copy Number Variation


In COSMIC - Cell Lines Project EPHX3 has gain in 1 cell-lines, loss in 1 cell-lines and no signal in 1002 cell-lines. (see details)

Gene Expression


In NCI60, the highest expressing cell lines are:

In Array Express (RNA-seq of 675 commonly used human cancer cell lines), the highest expressing cell lines are: NCI-H2347, COR-L279, NCI-H441

In Array Express (RNA-seq of long poly adenylated RNA and long non poly adenylated RNA from ENCODE cell lines), the highest expressing cell lines are: SK-N-SH, NHLF, HSMM

(see details)

3D Structures


At greater than 35% identity similarity to EPHX3 there are:
4 structures (8 chains) solved
2 are solved in complex with at least one small molecule ligand



(see details)
Molecular Target 3D Synopsis