Molecular Target Synopsis
Domains and Structures
Drugs and Clinical Candidates
Ligand Efficiency Plot
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
Germline Genetics

NSUN3 (Q9H649) - Overview - Molecular Target Synopsis


NSUN3, tRNA (cytosine(34)-C(5))-methyltransferase, mitochondrial
Enzyme Classification 2.1.1.-
UniProt Q9H649

Also Known as NSUN3_HUMAN, NSUN3

Mitochondrial tRNA methyltransferase that mediates methylation of cytosine to 5-methylcytosine (m5C) at position 34 of mt-tRNA(Met) (PubMed:27497299, PubMed:27214402, PubMed:27356879). mt-tRNA(Met) methylation at cytosine(34) takes place at the wobble position of the anticodon and initiates the formation of 5-formylcytosine (f(5)c) at this position (PubMed:27497299, PubMed:27214402, PubMed:27356879). mt-tRNA(Met) containing the f(5)c modification at the wobble position enables recognition of the AUA codon in addition to the AUG codon, expanding codon recognition in mitochondrial translation (PubMed:27497299, PubMed:27356879).

Isoforms / Transcripts (Protein Coding)

Protein Length Ensembl Gene Ensembl Transcript Ensembl Protein Uniprot Isoform

Sub-cellular localization

UniProt: NSUN3 is active in the following subcellular-locations: mitochondrion matrix.
GO terms: NSUN3 is active in the following subcellular-locations: mitochondrial large ribosomal subunit, mitochondrial matrix, mitochondrion.

GO terms

Gene Copy Number Variation

In COSMIC - Cell Lines Project NSUN3 has gain in 6 cell-lines, loss in 1 cell-lines and no signal in 997 cell-lines. (see details)

Gene Expression

In NCI60, the highest expressing cell lines are: SK_MEL_2, UACC_257, COLO205

In Array Express (RNA-seq of 675 commonly used human cancer cell lines), the highest expressing cell lines are: NCI-H1793, KYSE-140, NCI-H2172

In Array Express (RNA-seq of long poly adenylated RNA and long non poly adenylated RNA from ENCODE cell lines), the highest expressing cell lines are: SK-N-SH, HSMM, HMEC

(see details)

3D Structures

At greater than 35% identity similarity to NSUN3 there are:
1 structures (4 chains) solved
0 are solved in complex with at least one small molecule ligand

(see details)
Molecular Target 3D Synopsis