Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
Chemistry
Ligand Efficiency Plot
Pathways
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
RNAi
Mutations
Germline Genetics

NSUN3 (Q9H649) - Overview - Molecular Target Synopsis

Protein


NSUN3, tRNA (cytosine(34)-C(5))-methyltransferase, mitochondrial
Enzyme Classification 2.1.1.-
UniProt Q9H649

Also Known as NSUN3_HUMAN, NSUN3

Mitochondrial tRNA methyltransferase that mediates methylation of cytosine to 5-methylcytosine (m5C) at position 34 of mt-tRNA(Met) (PubMed:27497299, PubMed:27214402, PubMed:27356879). mt-tRNA(Met) methylation at cytosine(34) takes place at the wobble position of the anticodon and initiates the formation of 5-formylcytosine (f(5)c) at this position (PubMed:27497299, PubMed:27214402, PubMed:27356879). mt-tRNA(Met) containing the f(5)c modification at the wobble position enables recognition of the AUA codon in addition to the AUG codon, expanding codon recognition in mitochondrial translation (PubMed:27497299, PubMed:27356879).

Isoforms / Transcripts (Protein Coding)


Protein Length Ensembl Gene Ensembl Transcript Ensembl Protein Uniprot Isoform
340ENSG00000178694ENST00000314622ENSP00000318986Q9H649-1
77ENSG00000178694ENST00000483378ENSP00000419297

Sub-cellular localization


UniProt: NSUN3 is active in the following subcellular-locations: mitochondrion matrix.
GO terms: NSUN3 is active in the following subcellular-locations: mitochondrial large ribosomal subunit, mitochondrial matrix, mitochondrion.



UniProt
GO terms

Gene Copy Number Variation


In COSMIC - Cell Lines Project NSUN3 has gain in 6 cell-lines, loss in 1 cell-lines and no signal in 997 cell-lines. (see details)

Gene Expression


In NCI60, the highest expressing cell lines are: SK_MEL_2, UACC_257, COLO205

In Array Express (RNA-seq of 675 commonly used human cancer cell lines), the highest expressing cell lines are: NCI-H1793, KYSE-140, NCI-H2172

In Array Express (RNA-seq of long poly adenylated RNA and long non poly adenylated RNA from ENCODE cell lines), the highest expressing cell lines are: SK-N-SH, HSMM, HMEC

(see details)

3D Structures


At greater than 35% identity similarity to NSUN3 there are:
1 structures (4 chains) solved
0 are solved in complex with at least one small molecule ligand



(see details)
Molecular Target 3D Synopsis