Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
Chemistry
Ligand Efficiency Plot
Pathways
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
RNAi
Mutations
Germline Genetics

RERGL (Q9H628) - Overview - Molecular Target Synopsis

Protein


RERGL, Ras-related and estrogen-regulated growth inhibitor-like protein
UniProt Q9H628

Also Known as RERGL_HUMAN, RERGL

Binds GDP/GTP and may possess intrinsic GTPase activity.

Isoforms / Transcripts (Protein Coding)


Sub-cellular localization


GO terms: RERGL is active in the following subcellular-locations: membrane.



UniProt
GO terms

Gene Copy Number Variation


In COSMIC - Cell Lines Project RERGL has gain in 9 cell-lines, loss in 5 cell-lines and no signal in 991 cell-lines. (see details)

Gene Expression


In NCI60, the highest expressing cell lines are: MCF7, SK_OV_3, TK_10

In Array Express (RNA-seq of 675 commonly used human cancer cell lines), the highest expressing cell lines are: NCI-N417, CAL-148, SNU-398

In Array Express (RNA-seq of long poly adenylated RNA and long non poly adenylated RNA from ENCODE cell lines), the highest expressing cell lines are: SK-N-SH, NHLF, HSMM

(see details)

3D Structures


At greater than 35% identity similarity to RERGL there are:
4 structures (4 chains) solved
3 are solved in complex with at least one small molecule ligand



(see details)
Molecular Target 3D Synopsis