Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
Chemistry
Ligand Efficiency Plot
Pathways
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
RNAi
Mutations
Germline Genetics

TFB2M (Q9H5Q4) - Overview - Molecular Target Synopsis

Protein


TFB2M, Dimethyladenosine transferase 2, mitochondrial
Enzyme Classification 2.1.1.-
UniProt Q9H5Q4

Also Known as TFB2M_HUMAN, TFB2M, NS5ATP5

S-adenosyl-L-methionine-dependent methyltransferase which specifically dimethylates mitochondrial 12S rRNA at the conserved stem loop. Also required for basal transcription of mitochondrial DNA, probably via its interaction with POLRMT and TFAM. Stimulates transcription independently of the methyltransferase activity. Compared to TFB1M, it activates transcription of mitochondrial DNA more efficiently, while it has less methyltransferase activity. Interacts with mitochondrial RNA polymerase POLRMT. Interacts with TFAM.

6ERO
STRUCTURE OF HUMAN TFB2M
RCSB/PDB
Inspect Structure
See all 3D Structures for TFB2M

Isoforms / Transcripts (Protein Coding)


Protein Length Ensembl Gene Ensembl Transcript Ensembl Protein Uniprot Isoform
396ENSG00000162851ENST00000366514ENSP00000355471Q9H5Q4-1
137ENSG00000162851ENST00000544618ENSP00000442426

Sub-cellular localization


UniProt: TFB2M is active in the following subcellular-locations: mitochondrion.
GO terms: TFB2M is active in the following subcellular-locations: mitochondrial matrix, mitochondrial nucleoid, mitochondrion.



UniProt
GO terms

Gene Copy Number Variation


In COSMIC - Cell Lines Project TFB2M has gain in 5 cell-lines, loss in 0 cell-lines and no signal in 1000 cell-lines. (see details)

Gene Expression


In NCI60, the highest expressing cell lines are: K_562, RPMI_8226, MDA_N

In Array Express (RNA-seq of 675 commonly used human cancer cell lines), the highest expressing cell lines are: DV-90, A-375, KYSE-150

In Array Express (RNA-seq of long poly adenylated RNA and long non poly adenylated RNA from ENCODE cell lines), the highest expressing cell lines are: SK-N-SH, NHLF, HeLa-S3

(see details)

3D Structures


For TFB2M there are:
3 structures (6 chains) solved
0 are solved in complex with at least one small molecule ligand



(see details)
Molecular Target 3D Synopsis