POMK (Q9H5K3) - Overview - Molecular Target Synopsis
POMK, Protein O-mannose kinase
Enzyme Classification 18.104.22.168
Also Known as SG196_HUMAN, POMK, SGK196
Protein O-mannose kinase that specifically mediates phosphorylation at the 6-position of an O-mannose of the trisaccharide (N-acetylgalactosamine (GalNAc)-beta-1,3-N-acetylglucosamine (GlcNAc)-beta-1,4-mannose) to generate phosphorylated O-mannosyl trisaccharide (N-acetylgalactosamine-beta-1,3-N-acetylglucosamine-beta-1,4-(phosphate-6-)mannose). Phosphorylated O-mannosyl trisaccharide is a carbohydrate structure present in alpha-dystroglycan (DAG1), which is required for binding laminin G-like domain-containing extracellular proteins with high affinity. Only shows kinase activity when the GalNAc-beta-3-GlcNAc-beta-terminus is linked to the 4-position of O-mannose, suggesting that this disaccharide serves as the substrate recognition motif.
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UniProt: POMK is active in the following subcellular-locations: endoplasmic reticulum membrane.
GO terms: POMK is active in the following subcellular-locations: endoplasmic reticulum membrane, integral component of membrane.