Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
Chemistry
Ligand Efficiency Plot
Pathways
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
RNAi
Mutations
Germline Genetics

GSTO2 (Q9H4Y5) - Overview - Molecular Target Synopsis

Protein


GSTO2, Glutathione S-transferase omega-2
Enzyme Classification 2.5.1.18
UniProt Q9H4Y5

Also Known as GSTO2_HUMAN, GSTO2

Exhibits glutathione-dependent thiol transferase activity. Has high dehydroascorbate reductase activity and may contribute to the recycling of ascorbic acid. Participates in the biotransformation of inorganic arsenic and reduces monomethylarsonic acid (MMA).

3Q18
HUMAN GLUTATHIONE TRANSFERASE O2
RCSB/PDB
Inspect Structure
See all 3D Structures for GSTO2

Isoforms / Transcripts (Protein Coding)


Sub-cellular localization


GO terms: GSTO2 is active in the following subcellular-locations: cytosol, extracellular exosome.



UniProt
GO terms

Gene Copy Number Variation


In COSMIC - Cell Lines Project GSTO2 has gain in 1 cell-lines, loss in 0 cell-lines and no signal in 1004 cell-lines. (see details)

Gene Expression


In NCI60, the highest expressing cell lines are: HCT_116, KM12, MCF7

In Array Express (RNA-seq of 675 commonly used human cancer cell lines), the highest expressing cell lines are: ATRFLOX, HCT 116, NCI-H1573

In Array Express (RNA-seq of long poly adenylated RNA and long non poly adenylated RNA from ENCODE cell lines), the highest expressing cell lines are: SK-N-SH, NHLF, HSMM

(see details)

3D Structures


For GSTO2 there are:
3 structures (5 chains) solved
2 are solved in complex with at least one small molecule ligand



(see details)
Molecular Target 3D Synopsis

Screening and Chemistry


GSTO2 has been screened with 2 compounds (2 bioactivities). (see details)