Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
Chemistry
Ligand Efficiency Plot
Pathways
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
RNAi
Mutations
Germline Genetics

SERHL2 (Q9H4I8) - Overview - Molecular Target Synopsis

Protein


SERHL2, Serine hydrolase-like protein 2
Enzyme Classification 3.1.-.-
UniProt Q9H4I8

Also Known as SEHL2_HUMAN, SERHL2, SERHL

Probable serine hydrolase. May be related to cell muscle hypertrophy.

Isoforms / Transcripts (Protein Coding)


Sub-cellular localization


UniProt: SERHL2 is active in the following subcellular-locations: cytoplasm, perinuclear region, peroxisome.
GO terms: SERHL2 is active in the following subcellular-locations: cytoplasmic vesicle, perinuclear region of cytoplasm, peroxisome.



UniProt
GO terms

Gene Copy Number Variation


In COSMIC - Cell Lines Project SERHL2 has gain in 1 cell-lines, loss in 0 cell-lines and no signal in 1004 cell-lines. (see details)

Gene Expression


In NCI60, the highest expressing cell lines are: MOLT_4, K_562, CCRF_CEM

In Array Express (RNA-seq of 675 commonly used human cancer cell lines), the highest expressing cell lines are: YMB-1, ZR-75-1, YMB-1-E

In Array Express (RNA-seq of long poly adenylated RNA and long non poly adenylated RNA from ENCODE cell lines), the highest expressing cell lines are: K562, NHLF, HSMM

(see details)


Screening and Chemistry


SERHL2 has been screened with compounds ( bioactivities). (see details)