RHOJ (Q9H4E5) - Overview - Molecular Target Synopsis
RHOJ, Rho-related GTP-binding protein RhoJ
Also Known as RHOJ_HUMAN, RHOJ, ARHJ, RASL7B, RHOI, TCL
Plasma membrane-associated small GTPase specifically involved in angiogenesis (PubMed:21628409, PubMed:24434213, PubMed:30158707). Required for endothelial cell migration during vascular development via its interaction with GLUL (PubMed:30158707). Elicits the formation of F-actin-rich structures, thereby regulating endothelial cell migration (PubMed:30158707). Interacts with the CRIB domains of proteins such as Pak1 and Was/Wasp (By similarity). Interacts with GLUL (PubMed:30158707).
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UniProt: RHOJ is active in the following subcellular-locations: cell membrane.
GO terms: RHOJ is active in the following subcellular-locations: cell cortex, cell projection, cytoplasm, cytosol, extracellular exosome, plasma membrane.