Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
Chemistry
Ligand Efficiency Plot
Pathways
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
RNAi
Mutations
Germline Genetics

RHOJ (Q9H4E5) - Overview - Molecular Target Synopsis

Protein


RHOJ, Rho-related GTP-binding protein RhoJ
UniProt Q9H4E5

Also Known as RHOJ_HUMAN, RHOJ, ARHJ, RASL7B, RHOI, TCL

Plasma membrane-associated small GTPase specifically involved in angiogenesis (PubMed:21628409, PubMed:24434213, PubMed:30158707). Required for endothelial cell migration during vascular development via its interaction with GLUL (PubMed:30158707). Elicits the formation of F-actin-rich structures, thereby regulating endothelial cell migration (PubMed:30158707). Interacts with the CRIB domains of proteins such as Pak1 and Was/Wasp (By similarity). Interacts with GLUL (PubMed:30158707).

Isoforms / Transcripts (Protein Coding)


Sub-cellular localization


UniProt: RHOJ is active in the following subcellular-locations: cell membrane.
GO terms: RHOJ is active in the following subcellular-locations: cell cortex, cell projection, cytoplasm, cytosol, extracellular exosome, plasma membrane.



UniProt
GO terms

Gene Copy Number Variation


In COSMIC - Cell Lines Project RHOJ has gain in 5 cell-lines, loss in 0 cell-lines and no signal in 1000 cell-lines. (see details)

Gene Expression


In NCI60, the highest expressing cell lines are: SNB_19, SNB_75, MDA_MB_435

In Array Express (RNA-seq of 675 commonly used human cancer cell lines), the highest expressing cell lines are: C32TG, SK-MEL-24, WM-115

In Array Express (RNA-seq of long poly adenylated RNA and long non poly adenylated RNA from ENCODE cell lines), the highest expressing cell lines are: HUVEC, BJ, AG445

(see details)

3D Structures


At greater than 75% identity similarity to RHOJ there are:
1 structures (2 chains) solved
1 are solved in complex with at least one small molecule ligand



(see details)
Molecular Target 3D Synopsis

Screening and Chemistry


RHOJ has been screened with compounds ( bioactivities). (see details)