Molecular Target Synopsis
Domains and Structures
Drugs and Clinical Candidates
Ligand Efficiency Plot
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
Germline Genetics

DPEP3 (Q9H4B8) - Overview - Molecular Target Synopsis


DPEP3, Dipeptidase 3
Enzyme Classification
UniProt Q9H4B8

Also Known as DPEP3_HUMAN, DPEP3

Probable metalloprotease which hydrolyzes cystinyl-bis-glycine. May be involved in meiosis. Homodimer; disulfide-linked (By similarity). Interacts with TEX101; co-localized on the cell surface of spermatocytes, spermatids, and testicular spermatozoa, co-localized only in cytoplasmic droplets of caput and corpus epididymal sperm.

Isoforms / Transcripts (Protein Coding)

Protein Length Ensembl Gene Ensembl Transcript Ensembl Protein Uniprot Isoform

Sub-cellular localization

UniProt: DPEP3 is active in the following subcellular-locations: membrane.
GO terms: DPEP3 is active in the following subcellular-locations: acrosomal vesicle, anchored component of membrane, plasma membrane.

GO terms

Gene Copy Number Variation

In COSMIC - Cell Lines Project DPEP3 has gain in 1 cell-lines, loss in 2 cell-lines and no signal in 1002 cell-lines. (see details)

Gene Expression

In NCI60, the highest expressing cell lines are: MCF7, SK_OV_3, UACC_62

In Array Express (RNA-seq of 675 commonly used human cancer cell lines), the highest expressing cell lines are: 59M, HCC1482, SNU-484

In Array Express (RNA-seq of long poly adenylated RNA and long non poly adenylated RNA from ENCODE cell lines), the highest expressing cell lines are: SK-N-SH, NHLF, HSMM

(see details)

3D Structures

At greater than 35% identity similarity to DPEP3 there are:
23 structures (27 chains) solved
9 are solved in complex with at least one small molecule ligand

(see details)
Molecular Target 3D Synopsis

Screening and Chemistry

DPEP3 has been screened with compounds ( bioactivities). (see details)