Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
Chemistry
Ligand Efficiency Plot
Pathways
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
RNAi
Mutations
Germline Genetics

DPEP3 (Q9H4B8) - Overview - Molecular Target Synopsis

Protein


DPEP3, Dipeptidase 3
Enzyme Classification 3.4.13.19
UniProt Q9H4B8

Also Known as DPEP3_HUMAN, DPEP3

Probable metalloprotease which hydrolyzes cystinyl-bis-glycine. May be involved in meiosis. Homodimer; disulfide-linked (By similarity). Interacts with TEX101; co-localized on the cell surface of spermatocytes, spermatids, and testicular spermatozoa, co-localized only in cytoplasmic droplets of caput and corpus epididymal sperm.

Isoforms / Transcripts (Protein Coding)


Protein Length Ensembl Gene Ensembl Transcript Ensembl Protein Uniprot Isoform
513ENSG00000141096ENST00000268793ENSP00000268793
488Q9H4B8-1

Sub-cellular localization


UniProt: DPEP3 is active in the following subcellular-locations: membrane.
GO terms: DPEP3 is active in the following subcellular-locations: acrosomal vesicle, anchored component of membrane, plasma membrane.



UniProt
GO terms

Gene Copy Number Variation


In COSMIC - Cell Lines Project DPEP3 has gain in 1 cell-lines, loss in 2 cell-lines and no signal in 1002 cell-lines. (see details)

Gene Expression


In NCI60, the highest expressing cell lines are: MCF7, SK_OV_3, UACC_62

In Array Express (RNA-seq of 675 commonly used human cancer cell lines), the highest expressing cell lines are: 59M, HCC1482, SNU-484

In Array Express (RNA-seq of long poly adenylated RNA and long non poly adenylated RNA from ENCODE cell lines), the highest expressing cell lines are: SK-N-SH, NHLF, HSMM

(see details)

3D Structures


At greater than 35% identity similarity to DPEP3 there are:
23 structures (27 chains) solved
9 are solved in complex with at least one small molecule ligand



(see details)
Molecular Target 3D Synopsis

Screening and Chemistry


DPEP3 has been screened with compounds ( bioactivities). (see details)