Molecular Target Synopsis
Overview
Domains and Structures
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Druggability
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Ligand Efficiency Plot
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PLK3 (Q9H4B4) - Domains And Structures - Molecular Target Synopsis

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Structural Sequence Similarity Matches
Domains Covered Gene Name (Uniprot) Solved in Complex with Organism PDB Chain Identity E-Value Resolution Ligands Release Date
Protein kinase domain (100%) (view alignment) PLK1 (P53350) - HUMAN 4A4L_A 52.78 2.0E-88 2.35Å 939 TLA 2012-01-11
Protein kinase domain (100%) (view alignment) PLK1 (P53350) - HUMAN 4A4O_A 52.78 2.0E-88 2.7Å 664 TLA 2012-01-11
Protein kinase domain (100%) (view alignment) PLK1 (P53350) - HUMAN 2V5Q_A 52.58 9.0E-89 2.3Å - 2008-04-01
Protein kinase domain (100%) (view alignment) CIPK24 (Q9LDI3) - THALE CRESS 4D28_D 35.13 6.0E-43 3.3Å - 2014-10-15
Protein kinase domain (99%) (view alignment) PLK4 (O00444) - HUMAN 3COK_A 41.73 1.0E-61 2.25Å ANP 2008-04-15
Protein kinase domain (100%) (view alignment) (Q6DRK7) Map205 (P23226) LEOPARD DANIO,ZEBRA DANIO,ZEBRA FISH 4J7B_A 50.35 1.0E-88 2.3Å - 2013-07-24
Protein kinase domain (100%) (view alignment) (Q6DRK7) Map205 (P23226) LEOPARD DANIO,ZEBRA DANIO,ZEBRA FISH 4J7B_D 50.35 1.0E-88 2.3Å - 2013-07-24
Protein kinase domain (100%) (view alignment) (Q4KMI8) - ZEBRAFISH 3DBC_A 51.25 3.0E-89 3.35Å 2FR 2008-10-07
Protein kinase domain (100%) (view alignment) PLK1 (P53350) - HUMAN 4J52_A 53.38 1.0E-87 2.3Å 1J3 2013-05-29
Protein kinase domain (100%) (view alignment) PLK3 (Q9H4B4) - HUMAN 4B6L_A 100 0 1.8Å 9ZP 2013-08-21
POLO box duplicated region (94%) (view alignment) PLK2 (Q9NYY3) - HUMAN 4XB0_B 44.33 7.0E-43 2.7Å - 2015-05-06
POLO box duplicated region (94%) (view alignment) PLK2 (Q9NYY3) - HUMAN 4RS6_B 44.39 6.0E-45 2.6Å - 2014-12-03
Protein kinase domain (100%) (view alignment) PLK2 (Q9NYY3) - HUMAN 4I6B_A 66.67 3.0E-121 1.8Å 11G 2013-11-20
Protein kinase domain (100%) (view alignment) PLK1 (P53350) - HUMAN 2OU7_A 53.38 1.0E-87 2.4Å ANP 2007-04-24
Protein kinase domain (100%) (view alignment) PLK1 (P53350) - HUMAN 3THB_A 53.38 1.0E-87 2.5Å 3TA 2011-11-23
Protein kinase domain (100%) (view alignment) (Q4KMI8) - ZEBRA FISH 3DB8_A 51.25 3.0E-89 3.15Å 1FR 2008-10-07
Protein kinase domain (100%) (view alignment) PLK2 (Q9NYY3) - HUMAN 4I5M_A 66.67 3.0E-121 1.8Å R78 2013-12-25
Protein kinase domain (100%) (view alignment) CIPK24 (Q9LDI3) - THALE CRESS 4D28_B 35.13 6.0E-43 3.3Å - 2014-10-15
Protein kinase domain (99%) (view alignment) PLK4 (O00444) - HUMAN 3COK_B 41.73 1.0E-61 2.25Å ANP 2008-04-15
Protein kinase domain (100%) (view alignment) (Q4KMI8) - LEOPARD DANIO,ZEBRA DANIO,ZEBRA FISH 3D5W_A 51.6 6.0E-90 2.6Å ADP 2008-08-26
Protein kinase domain (100%) (view alignment) PLK1 (P53350) - HUMAN 5TA8_A 53.38 6.0E-88 2.6Å 79C 2017-02-22
Protein kinase domain (99%) (view alignment) SNF1 (P06782) - BAKER'S YEAST 2FH9_A 35.2 4.0E-39 2.8Å - 2006-03-28
Protein kinase domain (100%) (view alignment) (Q4KMI8) - ZEBRAFISH 3DBF_A 51.25 5.0E-89 3.2Å 5FR 2008-10-07
Protein kinase domain (100%) (view alignment) PLK1 (P53350) - HUMAN 2V5Q_B 52.58 9.0E-89 2.3Å - 2008-04-01
Protein kinase domain (100%) (view alignment) (Q4KMI8) - LEOPARD DANIO,ZEBRA DANIO,ZEBRA FISH 3D5X_A 51.25 5.0E-89 2.6Å KWT 2008-08-26
Protein kinase domain (100%) (view alignment) (Q6DRK7) - LEOPARD DANIO,ZEBRA DANIO,ZEBRA FISH 3D5U_A 51.6 6.0E-90 2.8Å - 2008-08-26
Protein kinase domain (100%) (view alignment) (Q4KMI8) - ZEBRAFISH 3DBE_A 51.25 5.0E-89 3.32Å 4FR 2008-10-07
Protein kinase domain (100%) (view alignment) (Q4KMI8) - ZEBRAFISH 3DBD_A 51.25 3.0E-89 3.05Å 3FR 2008-10-07
Protein kinase domain (98%) (view alignment) AURKC (Q9UQB9) INCENP (Q9NQS7) HUMAN 6GR8_A 35.63 6.0E-40 1.75Å F8Z 2019-05-15
Protein kinase domain (99%) (view alignment) PLK4 (O00444) - HUMAN 4JXF_A 41.73 2.0E-61 2.4Å 631 2014-04-02
Protein kinase domain (100%) (view alignment) (Q6DRK7) - LEOPARD DANIO,ZEBRA DANIO,ZEBRA FISH 3D5V_A 51.25 3.0E-89 2.4Å - 2008-08-26
Protein kinase domain (100%) (view alignment) PLK1 (P53350) - HUMAN 3KB7_A 52.78 2.0E-88 2.5Å 071 TLA 2010-05-19
Protein kinase domain (99%) (view alignment) SNF1 (P06782) - BREWER'S YEAST,LAGER BEER YEAST,YEAST 3MN3_A 35.2 4.0E-39 2.38Å - 2010-09-15
Protein kinase domain (100%) (view alignment) CIPK24 (Q9LDI3) - THALE CRESS 4D28_C 35.13 6.0E-43 3.3Å - 2014-10-15
POLO box duplicated region (94%) (view alignment) PLK2 (Q9NYY3) - HUMAN 4XB0_A 44.33 7.0E-43 2.7Å - 2015-05-06
Protein kinase domain (100%) (view alignment) PLK2 (Q9NYY3) - HUMAN 4I6F_A 66.67 3.0E-121 2.9Å 1C7 2013-11-20
Protein kinase domain (100%) (view alignment) PLK1 (P53350) - HUMAN 3FC2_A 53.38 1.0E-87 2.45Å IBI 2009-05-12
Protein kinase domain (100%) (view alignment) CIPK24 (Q9LDI3) - THALE CRESS 4D28_A 35.13 6.0E-43 3.3Å - 2014-10-15
Protein kinase domain (100%) (view alignment) PLK2 (Q9NYY3) - HUMAN 4I5P_A 66.67 3.0E-121 1.738Å 1D1 2013-12-25
Protein kinase domain (100%) (view alignment) PLK1 (P53350) - HUMAN 5TA6_A 53.38 6.0E-88 2.5Å 79D 2017-02-22
Protein kinase domain (100%) (view alignment) (Q4KMI8) - ZEBRA FISH 3DB6_A 51.25 5.0E-89 2.85Å FRS 2008-08-19
Protein kinase domain (98%) (view alignment) AURKC (Q9UQB9) INCENP (Q9NQS7) HUMAN 6GR9_A 35.63 6.0E-40 2.25Å VX6 2019-05-15
Protein kinase domain (100%) (view alignment) PLK1 (P53350) - HUMAN 2OWB_A 53.38 1.0E-87 2.1Å 626 2007-04-24
Protein kinase domain (100%) (view alignment) PLK1 (P53350) - HUMAN 2RKU_A 53.38 1.0E-87 1.95Å R78 TLA TAR 2008-02-05
Protein kinase domain (100%) (view alignment) PLK1 (P53350) - HUMAN 4J53_A 53.38 1.0E-87 2.5Å 1J4 2013-05-29
Protein kinase domain (100%) (view alignment) PLK1 (P53350) - HUMAN 2YAC_A 52.78 2.0E-88 2.2Å 937 TLA 2011-04-06
Protein kinase domain (99%) (view alignment) PLK4 (O00444) - HUMAN 4YUR_A 41.73 1.0E-61 2.65Å 4J7 2015-06-17
Protein kinase domain (100%) (view alignment) PLK2 (Q9NYY3) - HUMAN 4I6H_A 66.67 3.0E-121 1.9Å 1C8 2013-08-14
POLO box duplicated region (94%) (view alignment) PLK2 (Q9NYY3) - HUMAN 4RS6_A 44.39 6.0E-45 2.6Å - 2014-12-03