Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
Chemistry
Ligand Efficiency Plot
Pathways
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
RNAi
Mutations
Germline Genetics

DPEP2 (Q9H4A9) - Overview - Molecular Target Synopsis

Protein


DPEP2, Dipeptidase 2
Enzyme Classification 3.4.13.19
UniProt Q9H4A9

Also Known as DPEP2_HUMAN, DPEP2

Probable metalloprotease which hydrolyzes leukotriene D4 (LTD4) into leukotriene E4 (LTE4). Homodimer; disulfide-linked.

Isoforms / Transcripts (Protein Coding)


Sub-cellular localization


UniProt: DPEP2 is active in the following subcellular-locations: membrane.
GO terms: DPEP2 is active in the following subcellular-locations: anchored component of membrane.



UniProt
GO terms

Gene Copy Number Variation


In COSMIC - Cell Lines Project DPEP2 has gain in 1 cell-lines, loss in 2 cell-lines and no signal in 1002 cell-lines. (see details)

Gene Expression


In NCI60, the highest expressing cell lines are: LOXIMVI, NCI_H522, HCT_15

In Array Express (RNA-seq of 675 commonly used human cancer cell lines), the highest expressing cell lines are: UKE-1, KG-1, Hs 746T

In Array Express (RNA-seq of long poly adenylated RNA and long non poly adenylated RNA from ENCODE cell lines), the highest expressing cell lines are: CD14-positive monocyte, CD20-positive B cell, SK-N-SH

(see details)

3D Structures


At greater than 50% identity similarity to DPEP2 there are:
2 structures (4 chains) solved
2 are solved in complex with at least one small molecule ligand



(see details)
Molecular Target 3D Synopsis

Screening and Chemistry


DPEP2 has been screened with compounds ( bioactivities). (see details)