Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
Chemistry
Ligand Efficiency Plot
Pathways
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
RNAi
Mutations
Germline Genetics

GHITM (Q9H3K2) - Overview - Molecular Target Synopsis

Protein


GHITM, Growth hormone-inducible transmembrane protein
UniProt Q9H3K2

Also Known as GHITM_HUMAN, GHITM, DERP2, MICS1, TMBIM5

Required for the mitochondrial tubular network and cristae organization. Involved in apoptotic release of cytochrome c.

Isoforms / Transcripts (Protein Coding)


Protein Length Ensembl Gene Ensembl Transcript Ensembl Protein Uniprot Isoform
345ENSG00000165678ENST00000372134ENSP00000361207Q9H3K2-1

Sub-cellular localization


UniProt: GHITM is active in the following subcellular-locations: mitochondrion inner membrane.
GO terms: GHITM is active in the following subcellular-locations: extracellular exosome, integral component of membrane, mitochondrial inner membrane, mitochondrion.



UniProt
GO terms

Gene Copy Number Variation


In COSMIC - Cell Lines Project GHITM has gain in 1 cell-lines, loss in 1 cell-lines and no signal in 1003 cell-lines. (see details)

Gene Expression


In NCI60, the highest expressing cell lines are: NCI_H460, SW_620, T47D

In Array Express (RNA-seq of 675 commonly used human cancer cell lines), the highest expressing cell lines are: Hs 746T, KYSE-70, DV-90

In Array Express (RNA-seq of long poly adenylated RNA and long non poly adenylated RNA from ENCODE cell lines), the highest expressing cell lines are: NHLF, HeLa-S3, BJ

(see details)