Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
Chemistry
Ligand Efficiency Plot
Pathways
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
RNAi
Mutations
Germline Genetics

SPNS1 (Q9H2V7) - Overview - Molecular Target Synopsis

Protein


SPNS1, Protein spinster homolog 1
UniProt Q9H2V7

Also Known as SPNS1_HUMAN, SPNS1, SPIN1

Sphingolipid transporter (By similarity). May be involved in necrotic or autophagic cell death. Interacts with BCL2 and BCL2L1.

Isoforms / Transcripts (Protein Coding)


Sub-cellular localization


UniProt: SPNS1 is active in the following subcellular-locations: mitochondrion inner membrane.
GO terms: SPNS1 is active in the following subcellular-locations: integral component of membrane, lysosomal membrane, mitochondrial inner membrane.



UniProt
GO terms

Gene Copy Number Variation


In COSMIC - Cell Lines Project SPNS1 has gain in 1 cell-lines, loss in 0 cell-lines and no signal in 1004 cell-lines. (see details)

Gene Expression


In NCI60, the highest expressing cell lines are: SR, MCF7, MDA_N

In Array Express (RNA-seq of 675 commonly used human cancer cell lines), the highest expressing cell lines are: SNU-398, SK23, ACHN

In Array Express (RNA-seq of long poly adenylated RNA and long non poly adenylated RNA from ENCODE cell lines), the highest expressing cell lines are: SK-N-SH, NHLF, HSMM

(see details)