Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
Chemistry
Ligand Efficiency Plot
Pathways
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
RNAi
Mutations
Germline Genetics

TAOK3 (Q9H2K8) - Overview - Molecular Target Synopsis

Protein


TAOK3, Serine/threonine-protein kinase TAO3
Enzyme Classification 2.7.11.1
UniProt Q9H2K8

Also Known as TAOK3_HUMAN, TAOK3, DPK, JIK, KDS, MAP3K18

Serine/threonine-protein kinase that acts as a regulator of the p38/MAPK14 stress-activated MAPK cascade and of the MAPK8/JNK cascade. Acts as an activator of the p38/MAPK14 stress-activated MAPK cascade. In response to DNA damage, involved in the G2/M transition DNA damage checkpoint by activating the p38/MAPK14 stress-activated MAPK cascade, probably by mediating phosphorylation of upstream MAP2K3 and MAP2K6 kinases. Inhibits basal activity of MAPK8/JNK cascade and diminishes its activation in response epidermal growth factor (EGF). Self-associates. Interacts with ERN1 and TRAF2. Interaction with TRAF2 is facilitated under ER stress conditions, such as treatment with tunicamycin, and may promote TRAF2 phosphorylation.

6BDN
CRYSTAL STRUCTURE OF HUMAN TAO3 KINASE BINDING ADP
RCSB/PDB
Inspect Structure
See all 3D Structures for TAOK3

Isoforms / Transcripts (Protein Coding)


Sub-cellular localization


UniProt: TAOK3 is active in the following subcellular-locations: cell membrane, cytoplasm.
GO terms: TAOK3 is active in the following subcellular-locations: cytoplasm, nucleus, plasma membrane.



UniProt
GO terms

Gene Copy Number Variation


In COSMIC - Cell Lines Project TAOK3 has gain in 2 cell-lines, loss in 0 cell-lines and no signal in 1003 cell-lines. (see details)

Gene Expression


In NCI60, the highest expressing cell lines are: HL_60, CCRF_CEM, M14

In Array Express (RNA-seq of 675 commonly used human cancer cell lines), the highest expressing cell lines are: KG-1, UKE-1, HEL

In Array Express (RNA-seq of long poly adenylated RNA and long non poly adenylated RNA from ENCODE cell lines), the highest expressing cell lines are: NHLF, HSMM, AG445

(see details)

RNA Interference


TAOK3 was reported in the following RNAI studies:

Cell - Large Scale Profiling of Kinase Dependencies in Cancer Cell Lines, the highest RNAi cell lines are: HCH1, SCC36. (see details)

3D Structures


For TAOK3 there are:
1 structures (1 chains) solved
1 are solved in complex with at least one small molecule ligand



(see details)
Molecular Target 3D Synopsis

Screening and Chemistry


TAOK3 has been screened with 380 compounds (552 bioactivities), 89 compounds have bioactivities that show binding affinity of <= 500nM (91 bioactivities). (see details)