Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
Chemistry
Ligand Efficiency Plot
Pathways
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
RNAi
Mutations
Germline Genetics

SLK (Q9H2G2) - Overview - Molecular Target Synopsis

Protein


SLK, STE20-like serine/threonine-protein kinase
Enzyme Classification 2.7.11.1
UniProt Q9H2G2

Also Known as SLK_HUMAN, SLK, KIAA0204, STK2

Mediates apoptosis and actin stress fiber dissolution.

6HVD
HUMAN SLK BOUND TO A MALEIMIDE INHIBITOR
RCSB/PDB
Inspect Structure
See all 3D Structures for SLK

Isoforms / Transcripts (Protein Coding)


Protein Length Ensembl Gene Ensembl Transcript Ensembl Protein Uniprot Isoform
1235ENSG00000065613ENST00000369755ENSP00000358770Q9H2G2-1
1204ENSG00000065613ENST00000335753ENSP00000336824Q9H2G2-2

Sub-cellular localization


UniProt: SLK is active in the following subcellular-locations: cytoplasm.
GO terms: SLK is active in the following subcellular-locations: cell leading edge, cytoplasm, extracellular exosome, perinuclear region of cytoplasm.



UniProt
GO terms

Gene Copy Number Variation


In COSMIC - Cell Lines Project SLK has gain in 1 cell-lines, loss in 0 cell-lines and no signal in 1004 cell-lines. (see details)

Gene Expression


In NCI60, the highest expressing cell lines are: KM12, NCI_H322M, MDA_MB_231

In Array Express (RNA-seq of 675 commonly used human cancer cell lines), the highest expressing cell lines are: MKN-74, NCI-H1869, OCUM-1

In Array Express (RNA-seq of long poly adenylated RNA and long non poly adenylated RNA from ENCODE cell lines), the highest expressing cell lines are: NHLF, HMEC, NHEK

(see details)

RNA Interference


SLK was reported in the following RNAI studies:

Cell - Large Scale Profiling of Kinase Dependencies in Cancer Cell Lines, the highest RNAi cell lines are: BT549, ASPC1. (see details)

3D Structures


For SLK there are:
6 structures (7 chains) solved
5 are solved in complex with at least one small molecule ligand



(see details)
Molecular Target 3D Synopsis

Screening and Chemistry


SLK has been screened with 298 compounds (373 bioactivities), 33 compounds have bioactivities that show binding affinity of <= 500nM (55 bioactivities). (see details)