Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
Chemistry
Ligand Efficiency Plot
Pathways
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
RNAi
Mutations
Germline Genetics

ARV1 (Q9H2C2) - Overview - Molecular Target Synopsis

Protein


ARV1, Protein ARV1
UniProt Q9H2C2

Also Known as ARV1_HUMAN, ARV1

Plays a role as a mediator in the endoplasmic reticulum (ER) cholesterol and bile acid homeostasis (PubMed:11063737, PubMed:12145310, PubMed:20663892). Participates in sterol transport out of the ER and distribution into plasma membranes (PubMed:20663892).

Isoforms / Transcripts (Protein Coding)


Sub-cellular localization


UniProt: ARV1 is active in the following subcellular-locations: endoplasmic reticulum membrane.
GO terms: ARV1 is active in the following subcellular-locations: cortical endoplasmic reticulum, endoplasmic reticulum membrane, Golgi apparatus, integral component of membrane.



UniProt
GO terms

Gene Copy Number Variation


In COSMIC - Cell Lines Project ARV1 has gain in 3 cell-lines, loss in 0 cell-lines and no signal in 1002 cell-lines. (see details)

Gene Expression


In NCI60, the highest expressing cell lines are: MALME_3M, K_562, HL_60

In Array Express (RNA-seq of 675 commonly used human cancer cell lines), the highest expressing cell lines are: OCI-M1, SUM 229PE, SKM-1

In Array Express (RNA-seq of long poly adenylated RNA and long non poly adenylated RNA from ENCODE cell lines), the highest expressing cell lines are: NHLF, K562, HSMM

(see details)