Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
Chemistry
Ligand Efficiency Plot
Pathways
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
RNAi
Mutations
Germline Genetics

ABCG5 (Q9H222) - Overview - Molecular Target Synopsis

Protein


ABCG5, ATP-binding cassette sub-family G member 5
UniProt Q9H222

Also Known as ABCG5_HUMAN, ABCG5

ABCG5 and ABCG8 form an obligate heterodimer that mediates Mg(2+)- and ATP-dependent sterol transport across the cell membrane (PubMed:27144356). Plays an essential role in the selective transport of dietary plant sterols and cholesterol in and out of the enterocytes and in the selective sterol excretion by the liver into bile (PubMed:11099417, PubMed:11138003, PubMed:27144356, PubMed:15054092). Required for normal sterol homeostasis (PubMed:11099417, PubMed:11138003, PubMed:15054092). The heterodimer with ABCG8 has ATPase activity (PubMed:16893193, PubMed:20210363, PubMed:27144356). Heterodimer with ABCG8.

5DO7
CRYSTAL STRUCTURE OF THE HUMAN STEROL TRANSPORTER ABCG5/ABCG8
RCSB/PDB
Inspect Structure
See all 3D Structures for ABCG5

Isoforms / Transcripts (Protein Coding)


Sub-cellular localization


UniProt: ABCG5 is active in the following subcellular-locations: apical cell membrane, cell membrane.
GO terms: ABCG5 is active in the following subcellular-locations: apical plasma membrane, ATP-binding cassette (ABC) transporter complex, integral component of plasma membrane, plasma membrane, receptor complex.



UniProt
GO terms

Gene Copy Number Variation


In COSMIC - Cell Lines Project ABCG5 has gain in 2 cell-lines, loss in 0 cell-lines and no signal in 1003 cell-lines. (see details)

Gene Expression


In NCI60, the highest expressing cell lines are: SK_MEL_2, MCF7, TK_10

In Array Express (RNA-seq of 675 commonly used human cancer cell lines), the highest expressing cell lines are: Hep G2, Hs 746T, NCI-H209

In Array Express (RNA-seq of long poly adenylated RNA and long non poly adenylated RNA from ENCODE cell lines), the highest expressing cell lines are: SK-N-SH, NHLF, HSMM

(see details)

3D Structures


For ABCG5 there are:
1 structures (2 chains) solved
0 are solved in complex with at least one small molecule ligand



(see details)
Molecular Target 3D Synopsis

Screening and Chemistry


ABCG5 has been screened with compounds ( bioactivities). (see details)