Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
Chemistry
Ligand Efficiency Plot
Pathways
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
RNAi
Mutations
Germline Genetics

ABCG8 (Q9H221) - Overview - Molecular Target Synopsis

Protein


ABCG8, ATP-binding cassette sub-family G member 8
UniProt Q9H221

Also Known as ABCG8_HUMAN, ABCG8

ABCG5 and ABCG8 form an obligate heterodimer that mediates Mg(2+)- and ATP-dependent sterol transport across the cell membrane. Plays an essential role in the selective transport of the dietary cholesterol in and out of the enterocytes and in the selective sterol excretion by the liver into bile (PubMed:11099417, PubMed:11452359, PubMed:27144356, PubMed:15054092). Required for normal sterol homeostasis (PubMed:11099417, PubMed:11452359, PubMed:15054092). The heterodimer with ABCG5 has ATPase activity (PubMed:16893193, PubMed:20210363, PubMed:27144356). Heterodimer with ABCG8.

5DO7
CRYSTAL STRUCTURE OF THE HUMAN STEROL TRANSPORTER ABCG5/ABCG8
RCSB/PDB
Inspect Structure
See all 3D Structures for ABCG8

Isoforms / Transcripts (Protein Coding)


Protein Length Ensembl Gene Ensembl Transcript Ensembl Protein Uniprot Isoform
673ENSG00000143921ENST00000272286ENSP00000272286Q9H221-1
672Q9H221-2

Sub-cellular localization


UniProt: ABCG8 is active in the following subcellular-locations: apical cell membrane, cell membrane.
GO terms: ABCG8 is active in the following subcellular-locations: apical plasma membrane, ATP-binding cassette (ABC) transporter complex, integral component of plasma membrane, plasma membrane, receptor complex.



UniProt
GO terms

Gene Copy Number Variation


In COSMIC - Cell Lines Project ABCG8 has gain in 2 cell-lines, loss in 0 cell-lines and no signal in 1003 cell-lines. (see details)

Gene Expression


In NCI60, the highest expressing cell lines are: TK_10, ACHN, HS578T

In Array Express (RNA-seq of 675 commonly used human cancer cell lines), the highest expressing cell lines are: Hep G2, C3A, HuH-7

In Array Express (RNA-seq of long poly adenylated RNA and long non poly adenylated RNA from ENCODE cell lines), the highest expressing cell lines are: SK-N-SH, NHLF, HSMM

(see details)

3D Structures


For ABCG8 there are:
1 structures (2 chains) solved
0 are solved in complex with at least one small molecule ligand



(see details)
Molecular Target 3D Synopsis