Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
Chemistry
Ligand Efficiency Plot
Pathways
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
RNAi
Mutations
Germline Genetics

MYLK2 (Q9H1R3) - Overview - Molecular Target Synopsis

Protein


MYLK2, Myosin light chain kinase 2, skeletal/cardiac muscle
Enzyme Classification 2.7.11.18
UniProt Q9H1R3

Also Known as MYLK2_HUMAN, MYLK2

Implicated in the level of global muscle contraction and cardiac function. Phosphorylates a specific serine in the N-terminus of a myosin light chain. May interact with centrin.

2LV6
26 RESIDUE FRAGMENT OF
MYOSIN LIGHT CHAIN KINASE 2, SKELETAL/CARDIAC MUSCLE
IN THE STRUCTURE OF
THE COMPLEX BETWEEN CA-CALMODULIN AND SKELETAL MUSCLE MYOSIN LIGHT CHAIN KINASE FROM COMBINATION OF NMR AND AQUEOUS AND CONTRAST-MATCHED SAXS DATA
RCSB/PDB
Inspect Structure
See all 3D Structures for MYLK2

Isoforms / Transcripts (Protein Coding)


Protein Length Ensembl Gene Ensembl Transcript Ensembl Protein Uniprot Isoform
596ENSG00000101306ENST00000375985, ENST00000375994ENSP00000365152, ENSP00000365162Q9H1R3-1

Sub-cellular localization


UniProt: MYLK2 is active in the following subcellular-locations: cytoplasm.
GO terms: MYLK2 is active in the following subcellular-locations: cytoplasm, nucleus, sarcomere.



UniProt
GO terms

Gene Copy Number Variation


In COSMIC - Cell Lines Project MYLK2 has gain in 8 cell-lines, loss in 0 cell-lines and no signal in 996 cell-lines. (see details)

Gene Expression


In NCI60, the highest expressing cell lines are: CCRF_CEM, HCT_116, TK_10

In Array Express (RNA-seq of 675 commonly used human cancer cell lines), the highest expressing cell lines are: NCI-H2452, RPMI 8226, UKE-1

In Array Express (RNA-seq of long poly adenylated RNA and long non poly adenylated RNA from ENCODE cell lines), the highest expressing cell lines are: SK-N-SH, NHLF, HSMM

(see details)

RNA Interference


MYLK2 was reported in the following RNAI studies:

Cell - Large Scale Profiling of Kinase Dependencies in Cancer Cell Lines, the highest RNAi cell lines are: OAW42, SCC90. (see details)

3D Structures


For MYLK2 there are:
2 structures (3 chains) solved
0 are solved in complex with at least one small molecule ligand



(see details)
Molecular Target 3D Synopsis

Screening and Chemistry


MYLK2 has been screened with 150 compounds (221 bioactivities), 10 compounds have bioactivities that show binding affinity of <= 500nM (21 bioactivities). (see details)