Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
Chemistry
Ligand Efficiency Plot
Pathways
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Interaction Network
Gene Expression
Gene Copy Number Variation
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ASCC2 (Q9H1I8) - Overview - Molecular Target Synopsis

Protein


ASCC2, Activating signal cointegrator 1 complex subunit 2
UniProt Q9H1I8

Also Known as ASCC2_HUMAN, ASCC2, ASC1P100

Plays a role in DNA damage repair as component of the ASCC complex. Recruits ASCC3 and ALKBH3 to sites of DNA damage by binding to polyubiquitinated proteins that have 'Lys-63'-linked polyubiquitin chains (PubMed:29144457). Part of the ASC-1 complex that enhances NF-kappa-B, SRF and AP1 transactivation (PubMed:12077347). Identified in the ASCC complex that contains ASCC1, ASCC2 and ASCC3 (PubMed:29144457, PubMed:29997253). Interacts directly with ASCC3 (PubMed:29997253). The ASCC complex interacts with ALKBH3 (PubMed:29144457, PubMed:22055184). Interacts (via CUE domain) with 'Lys-63'-linked polyubiquitin chains, but not with 'Lys-48'-linked polyubiquitin chains (PubMed:29144457). Part of the ASC-1 complex, that contains TRIP4, ASCC1, ASCC2 and ASCC3 (PubMed:12077347). Interacts with CSRP1 (PubMed:26924529). Interacts with PRPF8, a component of the spliceosome (PubMed:29144457).

2DI0
SOLUTION STRUCTURE OF THE CUE DOMAIN IN THE HUMAN ACTIVATING SIGNAL COINTEGRATOR 1 COMPLEX SUBUNIT 2 (ASCC2)
RCSB/PDB
Inspect Structure
See all 3D Structures for ASCC2

Isoforms / Transcripts (Protein Coding)


Sub-cellular localization


UniProt: ASCC2 is active in the following subcellular-locations: nucleus, nucleus speckle.
GO terms: ASCC2 is active in the following subcellular-locations: activating signal cointegrator 1 complex, nuclear speck, nucleoplasm, nucleus.



UniProt
GO terms

Gene Copy Number Variation


In COSMIC - Cell Lines Project ASCC2 has gain in 0 cell-lines, loss in 2 cell-lines and no signal in 1002 cell-lines. (see details)

Gene Expression


In NCI60, the highest expressing cell lines are: SK_MEL_28, UACC_62, HL_60

In Array Express (RNA-seq of 675 commonly used human cancer cell lines), the highest expressing cell lines are: LN-18, HCC2688, NCI-H1975

In Array Express (RNA-seq of long poly adenylated RNA and long non poly adenylated RNA from ENCODE cell lines), the highest expressing cell lines are: SK-N-SH, IMR-90, HMEC

(see details)

3D Structures


For ASCC2 there are:
1 structures (1 chains) solved
0 are solved in complex with at least one small molecule ligand



(see details)
Molecular Target 3D Synopsis