ASCC2 (Q9H1I8) - Overview - Molecular Target Synopsis
ASCC2, Activating signal cointegrator 1 complex subunit 2
Also Known as ASCC2_HUMAN, ASCC2, ASC1P100
Plays a role in DNA damage repair as component of the ASCC complex. Recruits ASCC3 and ALKBH3 to sites of DNA damage by binding to polyubiquitinated proteins that have 'Lys-63'-linked polyubiquitin chains (PubMed:29144457). Part of the ASC-1 complex that enhances NF-kappa-B, SRF and AP1 transactivation (PubMed:12077347). Identified in the ASCC complex that contains ASCC1, ASCC2 and ASCC3 (PubMed:29144457, PubMed:29997253). Interacts directly with ASCC3 (PubMed:29997253). The ASCC complex interacts with ALKBH3 (PubMed:29144457, PubMed:22055184). Interacts (via CUE domain) with 'Lys-63'-linked polyubiquitin chains, but not with 'Lys-48'-linked polyubiquitin chains (PubMed:29144457). Part of the ASC-1 complex, that contains TRIP4, ASCC1, ASCC2 and ASCC3 (PubMed:12077347). Interacts with CSRP1 (PubMed:26924529). Interacts with PRPF8, a component of the spliceosome (PubMed:29144457).
|Protein Length||Ensembl Gene||Ensembl Transcript||Ensembl Protein||Uniprot Isoform|
|757||ENSG00000100325||ENST00000307790, ENST00000397771||ENSP00000305502, ENSP00000380877||Q9H1I8-1|
UniProt: ASCC2 is active in the following subcellular-locations: nucleus, nucleus speckle.
GO terms: ASCC2 is active in the following subcellular-locations: activating signal cointegrator 1 complex, nuclear speck, nucleoplasm, nucleus.