Molecular Target Synopsis
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TRPV6 (Q9H1D0) - Druggability - Molecular Target Synopsis

Chain-based assessment (last updated 02/07/2019)
Structural Druggability Help: Help

Chain-based assessment (last updated 02/07/2019)


Chains assessed24
Chains with at least one site assessed as druggable using the strict criteria21
Chains with at least one site assessed as druggable using the relaxed criteria24


		
PDB Chain Protein Name Druggable Relaxed Druggable Strict Details
6BO9_B Transient receptor potential cation channel subfamily V member 6 Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.06 65.4 57.6 Yes No
2 empty 1.81 69.4 50.6 No No
3 empty 2.25 62 33.2 No No
4 empty 2.17 49.4 21.5 No No
5 empty 1.95 59.4 20.9 No No
6 empty 1.77 62.3 29.1 No No
7 empty .92 66.8 17.4 No No
8 empty .55 63.2 23.4 No No
9 empty 2.11 64 17.2 No No
10 empty .94 68.7 18.6 No No
6D7T_A Transient receptor potential cation channel subfamily V member 6 Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 1.25 74.8 69.4 Yes Yes
2 empty 2.13 65.1 32.4 No No
3 empty 1.99 69.3 33 No No
4 empty 2.11 62.2 27.4 No No
5 empty .79 63.1 25.2 No No
6 empty 1.99 61.4 22.4 No No
7 empty 1.92 48.2 19 No No
8 empty 2 66.7 17.8 No No
9 empty 2.12 68 22.2 No No
10 empty .68 65.1 26 No No
6D7S_A Transient receptor potential cation channel subfamily V member 6 Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 1.55 70.4 50.4 Yes Yes
2 empty 2.06 69.5 41 No No
3 empty 2.33 66.4 33.1 No No
4 empty .8 63.7 24 No No
5 empty 2.03 43.9 20.9 No No
6 empty 2.19 61.7 20.6 No No
7 empty 2.05 60.8 20.6 No No
8 empty 2.11 62.7 27.2 No No
9 empty 1.77 60.4 24.1 No No
10 empty 1.86 64.7 16.4 No No
6BOA_C Transient receptor potential cation channel subfamily V member 6 Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 1.72 71.3 50.2 Yes Yes
2 empty 2.04 64.7 65 No No
3 empty 2.03 43.8 21 No No
4 empty 1.73 71.3 23.8 No No
5 empty 1.97 59.5 19.9 No No
6 empty 2.37 60.2 19.7 No No
7 empty .88 68 16.5 No No
8 empty 1.98 69.3 17.6 No No
9 empty 1.8 69.3 14 No No
10 empty 2.06 79.5 12 No No
6D7T_C Transient receptor potential cation channel subfamily V member 6 Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.18 67.6 67.8 Yes Yes
2 bound 1.32 81 28.1 Yes Yes
3 empty 2.03 68.6 33.4 No No
4 empty .64 63 25.1 No No
5 empty 2.04 60.9 20.1 No No
6 empty 1.9 46.8 19.3 No No
7 empty 2.03 67.3 18.2 No No
8 empty 2.09 69.3 21.9 No No
9 empty .67 65.6 18.9 No No
10 empty 2.25 63.2 17.3 No No
6E2F_C Transient receptor potential cation channel subfamily V member 6 Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 1.79 70.2 71.7 Yes Yes
2 empty 2.15 66.1 32.2 No No
3 empty 1.95 69.8 25.2 No No
4 empty 1.97 64.5 29.8 No No
5 empty 2.13 44.5 21 No No
6 empty .81 68.6 18.4 No No
7 empty 2.39 65 22.1 No No
8 empty 1.57 62.6 14.6 No No
9 empty .78 63.3 23.5 No No
10 empty 2.39 60.4 19.3 No No
6BOA_A Transient receptor potential cation channel subfamily V member 6 Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 1.81 70.1 47.9 Yes Yes
2 empty 2.06 68 55.5 No No
3 empty 2.25 61.3 37.8 No No
4 empty 2.04 44.6 22.1 No No
5 empty 2.07 67.9 21 No No
6 empty 1.65 67.3 23.8 No No
7 empty 2.67 83.5 16.3 No No
8 empty 2.31 59.2 19.8 No No
9 empty .87 67.2 16.3 No No
10 empty 1.89 68.1 14.7 No No
6BO8_B Transient receptor potential cation channel subfamily V member 6 Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.03 66.3 55.2 Yes Yes
2 empty 1.05 65.9 36.2 No No
3 empty 1.9 70.1 33.8 No No
4 empty 2.18 62.9 33.6 No No
5 empty 2.14 48.2 19.9 No No
6 empty 1.97 66 20.9 No No
7 empty .95 67.9 17.4 No No
8 empty 1.81 62.5 24.1 No No
9 empty 2.25 63.9 18 No No
10 empty 1.04 69.8 18.3 No No
6BOA_D Transient receptor potential cation channel subfamily V member 6 Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 1.78 69.2 49.5 Yes Yes
2 empty 1.98 67.2 50.4 No No
3 empty 2.09 60.4 37.6 No No
4 empty 2.12 44.1 22.2 No No
5 empty 1.98 65.1 20.3 No No
6 empty 1.73 69.7 23.7 No No
7 empty .84 66.5 17.1 No No
8 empty 2.62 82.5 15.9 No No
9 empty 2.32 60.6 20 No No
10 empty 1.81 69.4 16.8 No No
6BO9_D Transient receptor potential cation channel subfamily V member 6 Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 1.96 66.4 60.6 Yes Yes
2 empty 1 67.8 32.7 No No
3 empty 2.25 63.5 33.1 No No
4 empty 2.12 49.1 20.3 No No
5 empty 1.98 57 20.2 No No
6 empty 1.69 63.8 28.2 No No
7 empty .91 64.8 17 No No
8 empty .62 65.7 23.8 No No
9 empty 2.14 64.9 17.1 No No
10 empty .98 67.9 18.4 No No
6BO8_C Transient receptor potential cation channel subfamily V member 6 Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 1.83 67.2 68.6 Yes Yes
2 empty 2.04 62.4 24.5 No No
3 empty 2.16 48.2 20.2 No No
4 empty 1.95 65.8 20.8 No No
5 empty .94 65 17.6 No No
6 empty 2.2 67.2 20.6 No No
7 empty 1.67 65.5 24.1 No No
8 empty 2.11 62.7 18.3 No No
9 empty 1.21 67.9 14.9 No No
10 empty .52 61.6 23.3 No No
6BOA_B Transient receptor potential cation channel subfamily V member 6 Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.04 65.6 65.7 Yes No
2 empty 1.66 69.2 50.3 No No
3 empty 2.16 43.4 21.2 No No
4 empty 1.97 64.2 19.9 No No
5 empty 1.7 68.2 23.8 No No
6 empty 2.36 61.3 19.9 No No
7 empty 2.68 81.9 16 No No
8 empty .88 69.2 16.4 No No
9 empty 1.78 68.7 17.9 No No
10 empty 1.86 67 13.9 No No
6D7S_B Transient receptor potential cation channel subfamily V member 6 Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 1.54 67.4 51.3 Yes Yes
2 empty 2.09 69.6 37.5 No No
3 empty 2.28 66.8 30.6 No No
4 empty 2.06 44.6 20.7 No No
5 empty 2.29 62.7 24.7 No No
6 empty 2.05 58 21 No No
7 empty 1.76 61.9 22.1 No No
8 empty 1.96 63.5 23 No No
9 empty 1.85 64.4 16.4 No No
10 empty .58 65.5 18.7 No No
6BO8_A Transient receptor potential cation channel subfamily V member 6 Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.02 66.9 54.6 Yes Yes
2 empty 1.77 69.8 34.9 No No
3 empty 1.05 67.5 36.6 No No
4 empty 2.18 62.6 33.9 No No
5 empty 2.17 48.4 20.1 No No
6 empty 1.89 65.9 21.4 No No
7 empty 1.8 62.2 23.2 No No
8 empty 2.22 65.8 17.5 No No
9 empty 1.21 67.2 19.6 No No
10 empty .48 65.8 16 No No
6D7T_D Transient receptor potential cation channel subfamily V member 6 Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 1.19 75.2 61.9 Yes Yes
2 empty 2.14 64.8 31.9 No No
3 empty 1.98 68.6 34.5 No No
4 empty 2.12 63 27.7 No No
5 empty .65 63.1 25.1 No No
6 empty 1.93 59.7 21 No No
7 empty 1.92 47 19.7 No No
8 empty 2.03 67 18.1 No No
9 empty 2.1 70.2 19.1 No No
10 empty .42 66.3 23 No No
6E2F_D Transient receptor potential cation channel subfamily V member 6 Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 1.69 72.2 57.3 Yes Yes
2 empty 2.19 61.3 38.1 No No
3 empty 2.08 67.3 37.2 No No
4 empty 2.21 66.9 32.8 No No
5 empty 2.04 70.3 24.4 No No
6 empty 2.28 43.4 21.8 No No
7 empty .8 69.1 20.3 No No
8 empty 1.85 69.9 21.3 No No
9 empty 1.93 63.9 28.8 No No
10 empty 1.82 66.6 24.7 No No
6E2F_A Transient receptor potential cation channel subfamily V member 6 Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 1.92 71.9 59.3 Yes Yes
2 empty 2.21 64.7 31.9 No No
3 empty 2.19 68.3 26.4 No No
4 empty 2.01 68.6 24.8 No No
5 empty 2.2 42.2 19.8 No No
6 empty 2.23 74.3 19.1 No No
7 empty 1.85 61.6 20.1 No No
8 empty 1.69 65.2 21.4 No No
9 empty .86 67.6 19.1 No No
10 empty 2.42 60.6 19.9 No No
6E2F_B Transient receptor potential cation channel subfamily V member 6 Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.04 72.6 56.6 Yes Yes
2 empty 1.84 63.1 38.1 No No
3 empty 2.12 69.2 31.4 No No
4 empty 2.12 43.7 20.9 No No
5 empty 2.03 64.1 27.1 No No
6 empty 1.97 61.2 21.3 No No
7 empty 2.27 74.9 19.1 No No
8 empty 1.65 66 24.4 No No
9 empty 2.48 71.9 21.9 No No
10 empty .85 66.9 20.6 No No
6BO9_C Transient receptor potential cation channel subfamily V member 6 Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 1.96 67.3 60.2 Yes Yes
2 empty 1.06 68.7 34 No No
3 empty 2.14 61.7 33.3 No No
4 empty 2.2 46.5 20.8 No No
5 empty 2.1 60.4 20 No No
6 empty 1.75 65.6 23.9 No No
7 empty .93 65.6 17.1 No No
8 empty 2.06 65.2 18.3 No No
9 empty .53 63.5 24.3 No No
10 empty .92 68.7 14 No No
6D7S_C Transient receptor potential cation channel subfamily V member 6 Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 1.53 70.1 49 Yes Yes
2 empty 2.09 70 39.2 No No
3 empty 2.14 64.7 43.8 No No
4 empty 2.05 44.9 20.9 No No
5 empty 1.79 67.3 21.6 No No
6 empty .84 64 19.6 No No
7 empty 1.75 62.8 23.5 No No
8 empty 1.93 66.5 23.7 No No
9 empty 1.86 65.8 15.8 No No
10 empty 2.27 72.5 19.6 No No
6BO8_D Transient receptor potential cation channel subfamily V member 6 Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 1.86 67.3 59.6 Yes Yes
2 empty 1.06 66.8 39.5 No No
3 empty 2.2 62.9 34 No No
4 empty 2.1 52.8 19.8 No No
5 empty 2.07 58.4 21.1 No No
6 empty 1.78 63.3 23.4 No No
7 empty 2.14 64.9 18.1 No No
8 empty 1.05 69 16.4 No No
9 empty .76 62.7 23.6 No No
10 empty 1.56 90.9 15.6 Yes No
6D7T_B Transient receptor potential cation channel subfamily V member 6 Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 1.19 74.3 67.2 Yes Yes
2 empty 2.15 65.8 32.1 No No
3 empty 1.93 68.7 28.9 No No
4 empty 2.11 62.1 28 No No
5 empty .71 63.2 25.2 No No
6 empty 2.06 62 21 No No
7 empty 1.9 48.6 19.4 No No
8 empty 1.97 67.4 17.6 No No
9 empty 2.12 68.9 18.8 No No
10 empty 2.19 65.3 16.8 No No
6D7S_D Transient receptor potential cation channel subfamily V member 6 Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 1.89 71.9 47.5 Yes Yes
2 empty 2.1 69.8 38.4 No No
3 empty 2.27 66.4 31.1 No No
4 empty 2.04 49 23.6 No No
5 empty 2.19 61 20.8 No No
6 empty 2.04 57.8 20.6 No No
7 empty .66 64.2 19.8 No No
8 empty 1.77 62.3 23.6 No No
9 empty 1.94 66.7 22.2 No No
10 empty 1.89 65.7 15.3 No No
6BO9_A Transient receptor potential cation channel subfamily V member 6 Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.04 65.1 55.4 Yes No
2 empty 1.77 70.9 47 No No
3 empty 2.14 62.8 33.3 No No
4 empty 2.11 46.7 20.5 No No
5 empty 1.95 60.2 20.3 No No
6 empty 1.74 63.3 29.5 No No
7 empty .92 65.9 17 No No
8 empty .6 65.3 22.9 No No
9 empty 2.05 64.6 16.8 No No
10 empty 1.22 66.7 18 No No
Ligand-based Druggability Score: 0.85
Ligand-based Druggability Score Percentile: 89%
Ligand-based Druggability Help: Help




		
Number of proteins in the network : 13346


TRPV6 is involved in 15 interactions in the network.


Druggability
Overall Druggability Percentile: 41.01
Druggability for Cancer Therapeutics: 74.28
Druggability for Other Therapeutics: 34.81
Cancer-Associated
Cancer-associated percentile : 74.18
Network Articulation Point
Is TRPV6 critical for communication in the network?


Detailed Graph Legend:Help