Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
Chemistry
Ligand Efficiency Plot
Pathways
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
RNAi
Mutations
Germline Genetics

ABCG4 (Q9H172) - Overview - Molecular Target Synopsis

Protein


ABCG4, ATP-binding cassette sub-family G member 4
UniProt Q9H172

Also Known as ABCG4_HUMAN, ABCG4, WHITE2

May be involved in macrophage lipid homeostasis.

Isoforms / Transcripts (Protein Coding)


Sub-cellular localization


UniProt: ABCG4 is active in the following subcellular-locations: membrane.
GO terms: ABCG4 is active in the following subcellular-locations: integral component of membrane, plasma membrane.



UniProt
GO terms

Gene Copy Number Variation


In COSMIC - Cell Lines Project ABCG4 has gain in 1 cell-lines, loss in 4 cell-lines and no signal in 1000 cell-lines. (see details)

Gene Expression


In NCI60, the highest expressing cell lines are: SK_OV_3, MCF7, SNB_19

In Array Express (RNA-seq of 675 commonly used human cancer cell lines), the highest expressing cell lines are: Hs 746T, NCI-H209, LN-18

In Array Express (RNA-seq of long poly adenylated RNA and long non poly adenylated RNA from ENCODE cell lines), the highest expressing cell lines are: SK-N-SH, NHLF, HSMM

(see details)

3D Structures


At greater than 35% identity similarity to ABCG4 there are:
4 structures (8 chains) solved
0 are solved in complex with at least one small molecule ligand



(see details)
Molecular Target 3D Synopsis

Screening and Chemistry


ABCG4 has been screened with compounds ( bioactivities). (see details)