Molecular Target Synopsis
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RAB1B (Q9H0U4) - Druggability - Molecular Target Synopsis

Chain-based assessment (last updated 23/07/2019)
Domain-based assessment (last updated 30/07/2012)


Structural Druggability Help: Help

Chain-based assessment (last updated 23/07/2019)


Chains assessed20
Chains with at least one site assessed as druggable using the strict criteria4
Chains with at least one site assessed as druggable using the relaxed criteria16


		
PDB Chain Protein Name Druggable Relaxed Druggable Strict Details
4HLQ_D Ras-related protein Rab-1B Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 2.28 74.6 19.4 Yes No
2 empty 2.37 63.3 28.4 No No
3 empty 2.15 75.1 11.8 No No
4 empty 2.65 65 15 No No
5 empty 2.3 65.6 12.4 No No
6 empty 2.22 58.3 10.7 No No
7 empty 2.49 75.1 5.8 No No
8 empty 2.4 67.1 9.1 No No
9 empty 1.98 58.1 10.6 No No
10 empty 2.87 62.3 9.4 No No
5O74_H Ras-related protein Rab-1B No No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 2.14 61.7 22.8 No No
2 empty 2.29 66.9 14 No No
3 empty 2.16 64 18.5 No No
4 empty 1.94 73.1 9.6 No No
5 empty 2.74 62.6 15.6 No No
6 bound 1.73 58.3 14.6 No No
7 empty 2.76 62.6 16.2 No No
8 empty 1.95 59.3 15.5 No No
9 empty 2.29 55.3 13 No No
10 empty 2.38 55.1 11.3 No No
5SZK_B Ras-related protein Rab-1B Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 2.2 73.7 30.6 Yes No
2 empty 2.02 65.2 14.9 No No
3 empty 2.61 59.2 26.8 No No
4 empty 2.38 61.7 18.4 No No
5 empty 2.25 59.7 12 No No
6 empty 2.72 63.5 10.7 No No
7 empty 2.75 72.3 10.6 No No
8 empty 2.54 52.7 10.4 No No
9 empty 2 70.8 11.3 No No
10 empty 2.48 78.4 11.3 No No
5O74_F Ras-related protein Rab-1B Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 1.91 59.5 27 Yes No
2 empty 2.43 61.2 18.6 No No
3 empty 2.02 73.7 15.4 No No
4 empty 2.13 60.3 17.3 No No
5 empty 2.82 62.4 18.6 No No
6 empty 2.31 71.5 12.6 No No
7 empty 2.33 68.8 8.6 No No
8 bound 1.67 73.4 7.2 No No
9 empty 2.57 57.6 13.8 No No
10 empty 2.76 70.7 7.9 No No
4HLQ_H Ras-related protein Rab-1B Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 1.98 67.6 32.4 Yes Yes
2 bound 2.01 77.4 15.4 No No
3 empty 2.15 68.6 12.4 No No
4 empty 2.65 68.3 11.9 No No
5 empty 2.05 63.1 13.7 No No
6 empty 2.18 63.9 9.4 No No
7 empty 2.54 60.5 10.3 No No
8 empty 1.89 64.8 6.2 No No
9 empty 2.69 57.1 7.2 No No
10 empty 2 65.6 6.9 No No
5O74_D Ras-related protein Rab-1B Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.2 64.6 38 Yes No
2 bound 2.04 63.6 33 No No
3 empty 2.43 55.2 13.6 No No
4 empty 2.31 64.8 16.2 No No
5 empty 2.11 71.2 10.2 No No
6 empty 2.6 66.1 10.9 No No
7 empty 2.37 64.5 7.7 No No
8 empty 2.92 56.3 9.3 No No
9 empty 1.97 51.4 8.5 No No
10 empty 2.7 52.8 10.7 No No
5O74_B Ras-related protein Rab-1B No No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 2.06 63.6 23.5 No No
2 empty 2.37 62.1 21.7 No No
3 empty 1.83 72.7 19.8 No No
4 empty 2.73 59.2 24.5 No No
5 empty 2.26 65.3 23.6 No No
6 bound 1.81 68.1 11.2 No No
7 empty 2.16 74.9 9.7 No No
8 empty 1.97 64.2 13.1 No No
9 empty 2.94 60.9 10.8 No No
10 empty 2.37 54.8 11.6 No No
3JZA_A Ras-related protein Rab-1B Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.41 64.2 28.2 Yes No
2 empty 2.15 62.2 22.7 No No
3 empty 1.87 72 14.1 No No
4 empty 2.56 72 10 No No
5 empty 2.61 64.2 9.4 No No
6 empty 2.15 60.9 11.8 No No
7 empty 2.14 48.7 12.2 No No
8 empty 2.15 65.9 13.2 No No
9 empty 1.99 64.9 9.8 No No
10 empty 1.93 78.9 11.7 No No
3NKV_A Ras-related protein Rab-1B Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 2.24 75.9 28.9 Yes No
2 empty 2.52 63.1 37.5 No No
3 empty 2.83 71.7 10.3 No No
4 empty 1.54 59.9 11.7 No No
5 empty 2.59 58.8 10.8 No No
6 empty 2.49 68.9 9.2 No No
7 empty 2.48 77.5 9.5 No No
8 empty 2.63 62.2 7.6 No No
9 empty 1.95 63.2 6.9 No No
10 empty 2.81 61 6.5 No No
5O74_J Ras-related protein Rab-1B Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 1.88 62.1 24.2 Yes No
2 bound 2.09 54.2 17.6 No No
3 empty 1.77 75.5 13.2 No No
4 empty 2.49 58.6 17.2 No No
5 empty 2.2 69.3 10.6 No No
6 empty 2.28 69 13 No No
7 empty 2.53 68 16.1 No No
8 empty 2.15 53.2 13.1 No No
9 empty 2.37 80.3 13.6 No No
10 empty 2.24 66.1 12 No No
5O74_L Ras-related protein Rab-1B Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 1.85 59.2 34.2 Yes No
2 empty 2.19 67.6 23.4 No No
3 empty 2.27 58 19.8 No No
4 empty 1.88 67.6 14.6 No No
5 empty 2.27 75.2 11 No No
6 empty 2.63 57.5 14.7 No No
7 empty 2.26 60.8 13.1 No No
8 empty 2.65 53.5 10.2 No No
9 empty 2.43 61.6 13.2 No No
10 empty 1.61 66.9 7.5 No No
4I1O_A Ras-related protein Rab-1B Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 2.05 68.1 21.5 Yes Yes
2 empty 2.17 58.3 24 No No
3 empty 2.17 72.7 12 No No
4 empty 2.16 60.7 15.2 No No
5 empty 1.97 56.9 11.7 No No
6 empty 2.18 60.4 9.8 No No
7 empty 2 56 9.2 No No
8 empty 2.41 51.9 8.4 No No
9 empty 2.46 68.5 9.2 No No
10 empty 1.53 47 9.4 No No
4I1O_C Ras-related protein Rab-1B No No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 2.22 70.6 22.5 No No
2 empty 2.01 58.5 25.6 No No
3 empty 2.35 60.5 15.6 No No
4 bound 2.04 73.2 11 No No
5 empty 1.92 56.3 9.3 No No
6 empty 2.33 53 8.9 No No
7 empty 1.94 63.1 8.9 No No
8 empty 2.76 69.6 9.5 No No
9 empty 1.94 56.4 9.7 No No
10 bound 1.97 68.9 8.2 No No
5SZH_B Ras-related protein Rab-1B Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 2.16 81.3 21.8 Yes Yes
2 empty 2.57 61.2 29.4 No No
3 empty 2.68 65.7 25.7 No No
4 empty 2.42 61.5 19.2 No No
5 empty 2 65 11.4 No No
6 empty 2.43 66.8 9.2 No No
7 empty 1.61 77.7 8.7 No No
8 empty 2.4 62.2 9.1 No No
9 empty 2.32 56.6 9.9 No No
10 empty 2.35 70.8 8.1 No No
4I1O_G Ras-related protein Rab-1B No No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 2.06 69.8 20.6 No No
2 empty 1.94 57.9 25.6 No No
3 empty 1.96 71.9 11.4 No No
4 empty 2.13 60.3 16.5 No No
5 empty 2.04 57.3 8.9 No No
6 empty 2.25 60 9.8 No No
7 empty 2.72 67.1 7.4 No No
8 empty 1.79 65.2 8.1 No No
9 empty 1.93 57 7.4 No No
10 empty 2.26 58.7 7.8 No No
4I1O_E Ras-related protein Rab-1B Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 2.01 72.4 28.4 Yes Yes
2 empty 2.3 61.6 25.9 No No
3 empty 2.71 61.9 22.4 No No
4 empty 1.75 59.6 18.7 No No
5 empty 2.04 57.5 7.4 No No
6 empty 2.64 74.9 7.5 No No
7 empty 2.12 77.8 9.7 No No
8 empty 2.47 59 8.3 No No
9 empty 2.21 67.4 6.7 No No
10 empty 2.72 57.5 10.7 No No
4HLQ_B Ras-related protein Rab-1B Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 2.16 69 26.7 Yes No
2 empty 2.35 67.1 19.2 No No
3 empty 1.98 70.5 11.7 No No
4 empty 2.58 64.2 10.6 No No
5 empty 2.64 60.6 9.9 No No
6 empty 2.07 75.4 9.9 No No
7 empty 2.72 72.9 6.9 No No
8 empty 2.2 70.7 7.4 No No
9 empty 1.64 59 15 No No
10 empty 2.43 65.7 11.1 No No
4HLQ_J Ras-related protein Rab-1B Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 2.15 72.7 26.6 Yes No
2 empty 1.91 65.5 23.7 No No
3 empty 2.01 69.3 11.8 No No
4 empty 2.2 61.5 13.2 No No
5 empty 1.74 63.5 18.2 No No
6 empty 2.65 69.4 13 No No
7 empty 2.1 73.5 8.3 No No
8 empty 2.38 56.6 12 No No
9 empty 2.7 77.1 10.6 No No
10 empty 2.77 70 7.1 No No
3NKV_B Ras-related protein Rab-1B Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 2.28 76.6 26.2 Yes No
2 empty 2.61 71.2 23.1 No No
3 empty 2.59 64.6 26.3 No No
4 empty 2.16 66.7 16.3 No No
5 empty 2.24 57.4 17 No No
6 empty 1.81 76.8 9.1 No No
7 empty 1.99 60 9.3 No No
8 empty 1.77 70.5 9.9 No No
9 empty 2.66 60.5 9.4 No No
10 empty 2.42 68.9 11.8 No No
4HLQ_F Ras-related protein Rab-1B Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 2.1 66.4 29.1 Yes No
2 empty 2 64.5 21.2 No No
3 empty 2.67 63.6 12.8 No No
4 empty 2.4 59.6 19.4 No No
5 empty 2.21 72.2 12.1 No No
6 empty 2.41 76.1 10.3 No No
7 empty 2.78 70.7 8.5 No No
8 empty 2.2 61.5 8.5 No No
9 empty 1.65 74.8 9.1 No No
10 empty 3.13 64.7 7.1 No No

Domain-based assessment (last updated 30/07/2012)


Domains assessed2
Domains assessed as druggable using the strict criteria0
Domains assessed as druggable using the relaxed criteria2

PDB (Domain) Protein Name Domain Resolution Ligands Druggable Relaxed Druggable Strict
3JZA_A (3490464) Ras-related protein Rab-1B P-loop containing nucleoside triphosphate hydrolases, P-loop containing nucleoside triphosphate hydrolases, UNMATCHED 1.8Å Yes No
3NKV_A (3560793) Ras-related protein Rab-1B P-loop containing nucleoside triphosphate hydrolases, P-loop containing nucleoside triphosphate hydrolases, UNMATCHED 1.7Å Yes No
Ligand-based Druggability Score: -3
Ligand-based Druggability Score Percentile: 59%
Ligand-based Druggability Help: Help




		
Number of proteins in the network : 13346


RAB1B is involved in 12 interactions in the network.


Druggability
Overall Druggability Percentile: 40.39
Druggability for Cancer Therapeutics: 31.25
Druggability for Other Therapeutics: 60.55
Cancer-Associated
Cancer-associated percentile : 59.07
Network Articulation Point
Is RAB1B critical for communication in the network?


Detailed Graph Legend:Help