Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
Chemistry
Ligand Efficiency Plot
Pathways
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
RNAi
Mutations
Germline Genetics

RAB1B (Q9H0U4) - Overview - Molecular Target Synopsis

Protein


RAB1B, Ras-related protein Rab-1B
UniProt Q9H0U4

Also Known as RAB1B_HUMAN, RAB1B

The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different set of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion (PubMed:9437002). Plays a role in the initial events of the autophagic vacuole development which take place at specialized regions of the endoplasmic reticulum (PubMed:20545908). Regulates vesicular transport between the endoplasmic reticulum and successive Golgi compartments (By similarity). Promotes the recruitment of lipid phosphatase MTMR6 to the endoplasmic reticulum-Golgi intermediate compartment. Interacts with MICAL1 and MICAL2 (PubMed:15694364, PubMed:27552051). Interacts (in GTP-bound form) with MICALCL, MICAL1 and MILCAL3 (PubMed:15694364, PubMed:27552051). Interacts with GDI1; the interaction requires the GDP-bound state (PubMed:8836150, PubMed:11389151). Interacts with CHM/REP1; the interaction requires the GDP-bound form and is necessary for prenylation by GGTase II (PubMed:9437002, PubMed:11389151). Interacts with RabGAP TBC1D20 (PubMed:23236136). Interacts (in GDP-bound form) with lipid phosphatase MTMR6 (via GRAM domain); the interaction regulates MTMR6 recruitment to the endoplasmic reticulum-Golgi intermediate compartment (PubMed:23188820). Interacts (in GDP-bound form) with lipid phosphatase MTMR7.

5O74
CRYSTAL STRUCTURE OF HUMAN RAB1B COVALENTLY BOUND TO THE GEF DOMAIN OF DRRA/SIDM FROM LEGIONELLA PNEUMOPHILA IN THE PRESENCE OF GDP
RCSB/PDB
Inspect Structure
See all 3D Structures for RAB1B

Isoforms / Transcripts (Protein Coding)


Protein Length Ensembl Gene Ensembl Transcript Ensembl Protein Uniprot Isoform
201ENSG00000174903ENST00000311481ENSP00000310226Q9H0U4-1, Q5RE13-1
169ENSG00000174903ENST00000527397ENSP00000435195

Sub-cellular localization


UniProt: RAB1B is active in the following subcellular-locations: cytoplasm, membrane, perinuclear region, preautophagosomal structure membrane.
GO terms: RAB1B is active in the following subcellular-locations: cytosol, endoplasmic reticulum membrane, endoplasmic reticulum-Golgi intermediate compartment membrane, extracellular exosome, Golgi apparatus, Golgi membrane, phagophore assembly site membrane, transport vesicle.



UniProt
GO terms

Gene Copy Number Variation


In COSMIC - Cell Lines Project RAB1B has gain in 7 cell-lines, loss in 0 cell-lines and no signal in 998 cell-lines. (see details)

Gene Expression


In NCI60, the highest expressing cell lines are: T47D, RXF_393, EKVX

In Array Express (RNA-seq of 675 commonly used human cancer cell lines), the highest expressing cell lines are: Detroit 562, HuH-7, FaDu

In Array Express (RNA-seq of long poly adenylated RNA and long non poly adenylated RNA from ENCODE cell lines), the highest expressing cell lines are: HUVEC, SK-N-SH, HeLa-S3

(see details)

3D Structures


For RAB1B there are:
7 structures (20 chains) solved
6 are solved in complex with at least one small molecule ligand
1 are solved with an approved drug

RAB1B is solved in complex with the approved drug(s):

AMP/ADENOSINE PHOSPHATE (3NKV_A, 3NKV_B).

(see details)
Molecular Target 3D Synopsis

Screening and Chemistry


RAB1B has been screened with compounds ( bioactivities). (see details)