Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
Chemistry
Ligand Efficiency Plot
Pathways
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
RNAi
Mutations
Germline Genetics

RAB17 (Q9H0T7) - Overview - Molecular Target Synopsis

Protein


RAB17, Ras-related protein Rab-17
UniProt Q9H0T7

Also Known as RAB17_HUMAN, RAB17

The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different set of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion. That Rab is involved in transcytosis, the directed movement of endocytosed material through the cell and its exocytosis from the plasma membrane at the opposite side. Mainly observed in epithelial cells, transcytosis mediates for instance, the transcellular transport of immunoglobulins from the basolateral surface to the apical surface. Most probably controls membrane trafficking through apical recycling endosomes in a post-endocytic step of transcytosis. Required for melanosome transport and release from melanocytes, it also regulates dendrite and dendritic spine development (By similarity). May also play a role in cell migration.

Isoforms / Transcripts (Protein Coding)


Sub-cellular localization


UniProt: RAB17 is active in the following subcellular-locations: cell projection, dendrite, melanosome, recycling endosome membrane.
GO terms: RAB17 is active in the following subcellular-locations: apical plasma membrane, basolateral plasma membrane, dendrite, early endosome, endocytic vesicle, endosome, extracellular exosome, intracellular, melanosome, neuronal cell body, plasma membrane, recycling endosome, recycling endosome membrane.



UniProt
GO terms

Gene Copy Number Variation


In COSMIC - Cell Lines Project RAB17 has gain in 1 cell-lines, loss in 3 cell-lines and no signal in 1000 cell-lines. (see details)

Gene Expression


In NCI60, the highest expressing cell lines are: MALME_3M, SK_MEL_28, SK_MEL_5

In Array Express (RNA-seq of 675 commonly used human cancer cell lines), the highest expressing cell lines are: DMS 53, DMS 454, OUMS-23

In Array Express (RNA-seq of long poly adenylated RNA and long non poly adenylated RNA from ENCODE cell lines), the highest expressing cell lines are: MCF-7, SK-N-SH, NHLF

(see details)

3D Structures


At greater than 35% identity similarity to RAB17 there are:
126 structures (247 chains) solved
112 are solved in complex with at least one small molecule ligand
1 are solved with an approved drug

RAB17 is solved in complex with the approved drug(s):

AMP/ADENOSINE PHOSPHATE (3NKV_A, 3NKV_B).

(see details)
Molecular Target 3D Synopsis

Screening and Chemistry


RAB17 has been screened with compounds ( bioactivities). (see details)