Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
Chemistry
Ligand Efficiency Plot
Pathways
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
RNAi
Mutations
Germline Genetics

RAB6C (Q9H0N0) - Overview - Molecular Target Synopsis

Protein


RAB6C, Ras-related protein Rab-6C
UniProt Q9H0N0

Also Known as RAB6C_HUMAN, RAB6C, WTH3

May be involved in the regulation of centrosome duplication and cell cycle progression.

Isoforms / Transcripts (Protein Coding)


Protein Length Ensembl Gene Ensembl Transcript Ensembl Protein Uniprot Isoform
406ENSG00000222014ENST00000410061ENSP00000387307
254Q9H0N0-1

Sub-cellular localization


UniProt: RAB6C is active in the following subcellular-locations: centrosome, cytoplasm, cytoskeleton, microtubule organizing center, nucleus.
GO terms: RAB6C is active in the following subcellular-locations: centrosome, cytosol, Golgi apparatus, intracellular, nucleus.



UniProt
GO terms

Gene Copy Number Variation


In COSMIC - Cell Lines Project RAB6C has gain in 1 cell-lines, loss in 1 cell-lines and no signal in 1003 cell-lines. (see details)

Gene Expression


In NCI60, the highest expressing cell lines are:

In Array Express (RNA-seq of 675 commonly used human cancer cell lines), the highest expressing cell lines are: MDA-MB-134-VI, Hs 746T, NCI-H209

In Array Express (RNA-seq of long poly adenylated RNA and long non poly adenylated RNA from ENCODE cell lines), the highest expressing cell lines are: SK-N-SH, HSMM, NHLF

(see details)

3D Structures


At greater than 90% identity similarity to RAB6C there are:
2 structures (3 chains) solved
2 are solved in complex with at least one small molecule ligand



(see details)
Molecular Target 3D Synopsis