Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
Chemistry
Ligand Efficiency Plot
Pathways
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
RNAi
Mutations
Germline Genetics

SIK2 (Q9H0K1) - Overview - Molecular Target Synopsis

Protein


SIK2, Serine/threonine-protein kinase SIK2
Enzyme Classification 2.7.11.1
UniProt Q9H0K1

Also Known as SIK2_HUMAN, SIK2, KIAA0781, QIK, SNF1LK2

Phosphorylates 'Ser-794' of IRS1 in insulin-stimulated adipocytes, potentially modulating the efficiency of insulin signal transduction. Inhibits CREB activity by phosphorylating and repressing TORCs, the CREB-specific coactivators. Interacts with and phosphorylates TORC2/CRTC2.

Isoforms / Transcripts (Protein Coding)


Protein Length Ensembl Gene Ensembl Transcript Ensembl Protein Uniprot Isoform
926ENSG00000170145ENST00000304987ENSP00000305976Q9H0K1-1

Sub-cellular localization


UniProt: SIK2 is active in the following subcellular-locations: cytoplasm.
GO terms: SIK2 is active in the following subcellular-locations: cytoplasm, nucleotide-activated protein kinase complex, nucleus.



UniProt
GO terms

Gene Copy Number Variation


In COSMIC - Cell Lines Project SIK2 has gain in 6 cell-lines, loss in 8 cell-lines and no signal in 990 cell-lines. (see details)

Gene Expression


In NCI60, the highest expressing cell lines are: SK_MEL_5, MCF7, NCI_H460

In Array Express (RNA-seq of 675 commonly used human cancer cell lines), the highest expressing cell lines are: NCI-H1623, ChaGo-K-1, PLC/PRF/5

In Array Express (RNA-seq of long poly adenylated RNA and long non poly adenylated RNA from ENCODE cell lines), the highest expressing cell lines are: SK-N-SH, NHLF, BJ

(see details)

RNA Interference


SIK2 was reported in the following RNAI studies:

Cell - Large Scale Profiling of Kinase Dependencies in Cancer Cell Lines, the highest RNAi cell lines are: SUM44, A427. (see details)

3D Structures


At greater than 50% identity similarity to SIK2 there are:
16 structures (42 chains) solved
5 are solved in complex with at least one small molecule ligand



(see details)
Molecular Target 3D Synopsis

Screening and Chemistry


SIK2 has been screened with 516 compounds (938 bioactivities), 22 compounds have bioactivities that show binding affinity of <= 500nM (26 bioactivities). (see details)