Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
Chemistry
Ligand Efficiency Plot
Pathways
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
RNAi
Mutations
Germline Genetics

ARL6 (Q9H0F7) - Overview - Molecular Target Synopsis

Protein


ARL6, ADP-ribosylation factor-like protein 6
UniProt Q9H0F7

Also Known as ARL6_HUMAN, ARL6, BBS3

Involved in membrane protein trafficking at the base of the ciliary organelle. Mediates recruitment onto plasma membrane of the BBSome complex which would constitute a coat complex required for sorting of specific membrane proteins to the primary cilia (PubMed:20603001). Together with BBS1, is necessary for correct trafficking of PKD1 to primary cilia (By similarity). Together with the BBSome complex and LTZL1, controls SMO ciliary trafficking and contributes to the sonic hedgehog (SHH) pathway regulation (PubMed:22072986). May regulate cilia assembly and disassembly and subsequent ciliary signaling events such as the Wnt signaling cascade (PubMed:20207729). Isoform 2 may be required for proper retinal function and organization. Interacts with SEC61B, ARL6IP1, ARL6IP2, ARL6IP3, ARL6IP4 ARL6IP5 and ARL6IP6. Interacts (GTP-bound form) with the BBSome a complex that contains BBS1, BBS2, BBS4, BBS5, BBS7, BBS8/TTC8, BBS9 and BBIP10. Interacts (GTP-free form) with IFT27.

2H57
CRYSTAL STRUCTURE OF HUMAN ADP-RIBOSYLATION FACTOR-LIKE 6
RCSB/PDB
Inspect Structure
See all 3D Structures for ARL6

Isoforms / Transcripts (Protein Coding)


Sub-cellular localization


UniProt: ARL6 is active in the following subcellular-locations: cell projection, cilium axoneme, cilium basal body, cilium membrane, cytoplasm, cytoskeleton.
GO terms: ARL6 is active in the following subcellular-locations: axonemal microtubule, axoneme, cilium, cytoplasm, cytosol, extracellular exosome, membrane, membrane coat, plasma membrane.



UniProt
GO terms

Gene Copy Number Variation


In COSMIC - Cell Lines Project ARL6 has gain in 2 cell-lines, loss in 1 cell-lines and no signal in 1000 cell-lines. (see details)

Gene Expression


In NCI60, the highest expressing cell lines are: SK_MEL_2, OVCAR_3, MDA_N

In Array Express (RNA-seq of 675 commonly used human cancer cell lines), the highest expressing cell lines are: NCI-H82, SK-N-FI, SCLC-22H

In Array Express (RNA-seq of long poly adenylated RNA and long non poly adenylated RNA from ENCODE cell lines), the highest expressing cell lines are: SK-N-SH, HSMM, A549

(see details)

3D Structures


For ARL6 there are:
1 structures (3 chains) solved
1 are solved in complex with at least one small molecule ligand



(see details)
Molecular Target 3D Synopsis

Screening and Chemistry


ARL6 has been screened with compounds ( bioactivities). (see details)