Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
Chemistry
Ligand Efficiency Plot
Pathways
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
RNAi
Mutations
Germline Genetics

NUAK2 (Q9H093) - Overview - Molecular Target Synopsis

Protein


NUAK2, NUAK family SNF1-like kinase 2
Enzyme Classification 2.7.11.1
UniProt Q9H093

Also Known as NUAK2_HUMAN, NUAK2, OMPHK2, SNARK

Stress-activated kinase involved in tolerance to glucose starvation. Induces cell-cell detachment by increasing F-actin conversion to G-actin. Expression is induced by CD95 or TNF-alpha, via NF-kappa-B. Protects cells from CD95-mediated apoptosis and is required for the increased motility and invasiveness of CD95-activated tumor cells. Able to phosphorylate 'Ser-464' of LATS1.

Isoforms / Transcripts (Protein Coding)


Protein Length Ensembl Gene Ensembl Transcript Ensembl Protein Uniprot Isoform
628ENSG00000163545ENST00000367157ENSP00000356125Q9H093-1

Sub-cellular localization


GO terms: NUAK2 is active in the following subcellular-locations: cytoplasm, nucleus.



UniProt
GO terms

Gene Copy Number Variation


In COSMIC - Cell Lines Project NUAK2 has gain in 2 cell-lines, loss in 0 cell-lines and no signal in 1003 cell-lines. (see details)

Gene Expression


In NCI60, the highest expressing cell lines are:

In Array Express (RNA-seq of 675 commonly used human cancer cell lines), the highest expressing cell lines are: SNU-449, MKN-74, OVKATE

In Array Express (RNA-seq of long poly adenylated RNA and long non poly adenylated RNA from ENCODE cell lines), the highest expressing cell lines are: A549, SK-N-SH, IMR-90

(see details)

RNA Interference


NUAK2 was reported in the following RNAI studies:

Cell - Large Scale Profiling of Kinase Dependencies in Cancer Cell Lines, the highest RNAi cell lines are: OAW42, SUM149. (see details)

3D Structures


At greater than 50% identity similarity to NUAK2 there are:
11 structures (29 chains) solved
4 are solved in complex with at least one small molecule ligand



(see details)
Molecular Target 3D Synopsis

Screening and Chemistry


NUAK2 has been screened with 116 compounds (163 bioactivities), 22 compounds have bioactivities that show binding affinity of <= 500nM (33 bioactivities). (see details)