Molecular Target Synopsis
Domains and Structures
Drugs and Clinical Candidates
Ligand Efficiency Plot
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
Germline Genetics

RAB33B (Q9H082) - Overview - Molecular Target Synopsis


RAB33B, Ras-related protein Rab-33B
UniProt Q9H082

Also Known as RB33B_HUMAN, RAB33B

Protein transport. Acts, in coordination with RAB6A, to regulate intra-Golgi retrograde trafficking. It is involved in autophagy, acting as a modulator of autophagosome formation. Interacts with ATG16L (PubMed:21808068). Interaction with ATG16L is important for autophagosome formation (By similarity). Interacts with RIC1 (via C-terminus domain); the interaction is direct with a preference for RAB33B-GTP (PubMed:23091056). Interacts with RGP1 (PubMed:23091056).

Isoforms / Transcripts (Protein Coding)

Protein Length Ensembl Gene Ensembl Transcript Ensembl Protein Uniprot Isoform

Sub-cellular localization

UniProt: RAB33B is active in the following subcellular-locations: cis-golgi network, golgi apparatus, golgi apparatus membrane.
GO terms: RAB33B is active in the following subcellular-locations: endoplasmic reticulum membrane, Golgi apparatus, Golgi lumen, Golgi membrane, presynapse.

GO terms

Gene Copy Number Variation

In COSMIC - Cell Lines Project RAB33B has gain in 0 cell-lines, loss in 3 cell-lines and no signal in 1002 cell-lines. (see details)

Gene Expression

In NCI60, the highest expressing cell lines are: NCI_H522, SK_OV_3, SR

In Array Express (RNA-seq of 675 commonly used human cancer cell lines), the highest expressing cell lines are: Hs 746T, HM7, IM-95

In Array Express (RNA-seq of long poly adenylated RNA and long non poly adenylated RNA from ENCODE cell lines), the highest expressing cell lines are: SK-N-SH, A549, HMEC

(see details)

3D Structures

At greater than 90% identity similarity to RAB33B there are:
2 structures (2 chains) solved
2 are solved in complex with at least one small molecule ligand

(see details)
Molecular Target 3D Synopsis

Screening and Chemistry

RAB33B has been screened with compounds ( bioactivities). (see details)