Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
Chemistry
Ligand Efficiency Plot
Pathways
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
RNAi
Mutations
Germline Genetics

RAB33B (Q9H082) - Overview - Molecular Target Synopsis

Protein


RAB33B, Ras-related protein Rab-33B
UniProt Q9H082

Also Known as RB33B_HUMAN, RAB33B

Protein transport. Acts, in coordination with RAB6A, to regulate intra-Golgi retrograde trafficking. It is involved in autophagy, acting as a modulator of autophagosome formation. Interacts with ATG16L (PubMed:21808068). Interaction with ATG16L is important for autophagosome formation (By similarity). Interacts with RIC1 (via C-terminus domain); the interaction is direct with a preference for RAB33B-GTP (PubMed:23091056). Interacts with RGP1 (PubMed:23091056).

Isoforms / Transcripts (Protein Coding)


Protein Length Ensembl Gene Ensembl Transcript Ensembl Protein Uniprot Isoform
229ENSG00000172007ENST00000305626ENSP00000306496Q9H082-1

Sub-cellular localization


UniProt: RAB33B is active in the following subcellular-locations: cis-golgi network, golgi apparatus, golgi apparatus membrane.
GO terms: RAB33B is active in the following subcellular-locations: endoplasmic reticulum membrane, Golgi apparatus, Golgi lumen, Golgi membrane, presynapse.



UniProt
GO terms

Gene Copy Number Variation


In COSMIC - Cell Lines Project RAB33B has gain in 0 cell-lines, loss in 3 cell-lines and no signal in 1002 cell-lines. (see details)

Gene Expression


In NCI60, the highest expressing cell lines are: NCI_H522, SK_OV_3, SR

In Array Express (RNA-seq of 675 commonly used human cancer cell lines), the highest expressing cell lines are: Hs 746T, HM7, IM-95

In Array Express (RNA-seq of long poly adenylated RNA and long non poly adenylated RNA from ENCODE cell lines), the highest expressing cell lines are: SK-N-SH, A549, HMEC

(see details)

3D Structures


At greater than 90% identity similarity to RAB33B there are:
2 structures (2 chains) solved
2 are solved in complex with at least one small molecule ligand



(see details)
Molecular Target 3D Synopsis

Screening and Chemistry


RAB33B has been screened with compounds ( bioactivities). (see details)