Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
Chemistry
Ligand Efficiency Plot
Pathways
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
RNAi
Mutations
Germline Genetics

AICDA (Q9GZX7) - Druggability - Molecular Target Synopsis

Chain-based assessment (last updated 23/07/2019)
Structural Druggability Help: Help

Chain-based assessment (last updated 23/07/2019)


Chains assessed11
Chains with at least one site assessed as druggable using the strict criteria8
Chains with at least one site assessed as druggable using the relaxed criteria11


		
PDB Chain Protein Name Druggable Relaxed Druggable Strict Details
5W1C_B Single-stranded DNA cytosine deaminase Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.09 67.4 35.8 Yes Yes
2 empty 1.8 66.2 27.1 No No
3 empty 2.41 67.6 23.6 No No
4 empty 2 66 23.8 No No
5 bound 2.19 66.1 20.5 No No
6 empty 2.16 65.6 16 No No
7 empty 2.27 54.3 22.7 No No
8 empty 2.08 61.2 11.7 No No
9 empty 2.37 60.1 16.6 No No
10 empty 1.87 59.5 10.8 No No
5W0R_A Single-stranded DNA cytosine deaminase Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 1.81 70.9 48.1 Yes Yes
2 empty 2.1 58.3 34.7 No No
3 bound 1.94 65.7 28.4 No No
4 empty 2.17 64.1 15.9 No No
5 empty 1.66 60.2 17.4 No No
6 empty 2.38 58.9 16.9 No No
7 empty 2.1 59.9 16.3 No No
8 empty 2 57.1 19.3 No No
9 empty 2.54 66.4 12.6 No No
10 empty 2.21 67.6 11.3 No No
5W0R_B Single-stranded DNA cytosine deaminase Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 1.75 66.5 53.3 Yes Yes
2 bound 2.19 65.2 32.2 No No
3 empty 2.25 66.6 23.2 No No
4 empty 1.78 72.7 17.1 No No
5 empty 2.13 71.1 15.1 No No
6 empty 1.78 73 12.9 No No
7 empty 2.33 66.1 12.8 No No
8 empty 2.01 61.8 14.6 No No
9 empty 1.98 50.9 14.1 No No
10 empty 2.36 67.4 15.3 No No
5W0U_B Single-stranded DNA cytosine deaminase Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.05 68.1 26.4 Yes Yes
2 empty 1.91 64.8 26.6 No No
3 empty 1.79 65.5 24.5 No No
4 empty 2.46 68.5 21.9 No No
5 empty 1.97 67.7 16.8 No No
6 bound 2.1 70.5 17.9 No No
7 empty 2.17 63.9 15.9 No No
8 empty 2.25 55.7 22.6 No No
9 empty 2.19 62.4 12.8 No No
10 empty 2.25 59 15.4 No No
5W0U_A Single-stranded DNA cytosine deaminase Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.02 69 38.2 Yes Yes
2 bound 2.5 66.8 35.7 No No
3 empty 1.77 69.1 32.7 No No
4 empty 2.12 69 28.5 No No
5 empty 2.34 66.4 19.2 No No
6 empty 2.5 59.2 19 No No
7 empty 2.3 65.7 16.2 No No
8 empty 2.77 67.4 25 No No
9 empty 1.91 73.2 14.1 No No
10 empty 2.14 62.4 16.5 No No
5JJ4_A Single-stranded DNA cytosine deaminase Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 1.88 72.6 37.8 Yes No
2 empty 2.13 66 48.2 No No
3 bound 1.72 75.5 37.5 No No
4 empty 1.97 66.9 24.5 No No
5 empty 2.19 63.1 22.2 No No
6 empty 2.54 67.6 20.2 No No
7 empty 1.9 63.4 13.5 No No
8 empty 2.18 62.1 13.4 No No
9 empty 2.23 64 12.2 No No
10 empty 2.09 65.6 19.4 No No
5W0Z_A Single-stranded DNA cytosine deaminase Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 1.8 70.2 62.4 Yes Yes
2 empty 2.43 61.5 41.1 No No
3 empty 2.24 61.5 30.3 No No
4 empty 2.18 65.8 20.8 No No
5 empty 2.28 59.4 18 No No
6 empty 1.72 70.5 12.9 No No
7 empty 2.31 65.8 19.5 No No
8 empty 2.33 68.4 15.8 No No
9 empty 2.48 71.1 11.8 No No
10 empty 2.57 65.9 11.4 No No
5JJ4_B Single-stranded DNA cytosine deaminase Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 1.67 71.9 35.6 Yes Yes
2 empty 2.1 66.3 48.9 No No
3 bound 1.75 74.3 38.2 No No
4 empty 2.27 64.7 27.3 No No
5 empty 2.56 66.6 26 No No
6 empty 2.13 60.4 25.2 No No
7 empty 1.88 62.8 16.9 No No
8 empty 2.11 58.4 16.9 No No
9 empty 2.09 57.3 12.5 No No
10 empty 1.88 67.6 13.1 No No
5W1C_A Single-stranded DNA cytosine deaminase Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.05 65.3 36.2 Yes No
2 empty 1.63 65.3 29.6 No No
3 empty 2.05 66.6 21.6 No No
4 empty 2.29 67.9 25 No No
5 bound 2.36 68.1 19.4 No No
6 empty 2.17 64.5 15.7 No No
7 empty 2.27 53.7 22.6 No No
8 empty 2.43 59.5 14.3 No No
9 empty 2.26 61 14.8 No No
10 empty 1.71 69.5 12.3 No No
5W0Z_B Single-stranded DNA cytosine deaminase Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 1.74 70.1 61.6 Yes Yes
2 empty 2.32 63.4 41.1 No No
3 empty 2.25 61.5 29.5 No No
4 empty 2.15 64.4 19.2 No No
5 empty 2.32 62.3 16.5 No No
6 empty 2.05 60.8 16.9 No No
7 empty 2.4 73.1 16.9 No No
8 empty 1.81 68.3 11.7 No No
9 empty 2.51 60.6 16.4 No No
10 empty 2.53 67.7 11.8 No No
5JJ4_C Single-stranded DNA cytosine deaminase Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 1.79 73.1 34.1 Yes No
2 empty 2.24 70.6 36.3 No No
3 bound 1.62 80.1 24.8 No No
4 empty 2.49 64.8 25.8 No No
5 empty 1.98 61 23.5 No No
6 empty 2.48 66.9 24 No No
7 empty 2.27 64.3 20.7 No No
8 empty 2.19 58.5 17.5 No No
9 empty 2.15 71.8 11.8 No No
10 empty 2.19 71.4 11.7 No No
Ligand-based Druggability Score: -3
Ligand-based Druggability Score Percentile: 59%
Ligand-based Druggability Help: Help




		
Number of proteins in the network : 13346


AICDA is involved in 7 interactions in the network.


Druggability
Overall Druggability Percentile: 25.21
Druggability for Cancer Therapeutics: 52.54
Druggability for Other Therapeutics: 17.89
Cancer-Associated
Cancer-associated percentile : 58.62
Network Articulation Point
Is AICDA critical for communication in the network?


Detailed Graph Legend:Help