Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
Chemistry
Ligand Efficiency Plot
Pathways
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
RNAi
Mutations
Germline Genetics

AICDA (Q9GZX7) - Overview - Molecular Target Synopsis

Protein


AICDA, Single-stranded DNA cytosine deaminase
Enzyme Classification 3.5.4.38
UniProt Q9GZX7

Also Known as AICDA_HUMAN, AICDA, AID

Single-stranded DNA-specific cytidine deaminase. Involved in somatic hypermutation (SHM), gene conversion, and class-switch recombination (CSR) in B-lymphocytes by deaminating C to U during transcription of Ig-variable (V) and Ig-switch (S) region DNA. Required for several crucial steps of B-cell terminal differentiation necessary for efficient antibody responses (PubMed:18722174, PubMed:21385873, PubMed:21518874, PubMed:27716525). May also play a role in the epigenetic regulation of gene expression by participating in DNA demethylation (PubMed:21496894). Interacts with CTNNBL1; the interaction is important for the immunoglobulin switch activity of AICDA. Interacts (via its NLS) with KPNA1. Interacts with PKA/PRKACA and PRKAR1A/PKR1. Interacts with TRIM28 and NCL (By similarity). Interacts with SUPT6H. Interacts with RNF126.

5W0U
CRYSTAL STRUCTURE OF MBP FUSED ACTIVATION-INDUCED CYTIDINE DEAMINASE (AID) IN COMPLEX WITH DCMP
RCSB/PDB
Inspect Structure
See all 3D Structures for AICDA

Isoforms / Transcripts (Protein Coding)


Sub-cellular localization


UniProt: AICDA is active in the following subcellular-locations: cytoplasm, nucleus.
GO terms: AICDA is active in the following subcellular-locations: cytoplasm, nucleus, P-body.



UniProt
GO terms

Gene Copy Number Variation


In COSMIC - Cell Lines Project AICDA has gain in 6 cell-lines, loss in 2 cell-lines and no signal in 997 cell-lines. (see details)

Gene Expression


In NCI60, the highest expressing cell lines are: HOP_92, SNB_19, UACC_62

In Array Express (RNA-seq of 675 commonly used human cancer cell lines), the highest expressing cell lines are: OCI-LY-10, Daudi, SU-DHL-5

In Array Express (RNA-seq of long poly adenylated RNA and long non poly adenylated RNA from ENCODE cell lines), the highest expressing cell lines are: SK-N-SH, NHLF, HSMM

(see details)

3D Structures


For AICDA there are:
5 structures (11 chains) solved
3 are solved in complex with at least one small molecule ligand



(see details)
Molecular Target 3D Synopsis

Screening and Chemistry


AICDA has been screened with compounds ( bioactivities). (see details)