Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
Chemistry
Ligand Efficiency Plot
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Interaction Network
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Gene Copy Number Variation
RNAi
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Germline Genetics

IL22 (Q9GZX6) - Druggability - Molecular Target Synopsis

Chain-based assessment (last updated 23/07/2019)
Domain-based assessment (last updated 30/07/2012)


Structural Druggability Help: Help

Chain-based assessment (last updated 23/07/2019)


Chains assessed14
Chains with at least one site assessed as druggable using the strict criteria1
Chains with at least one site assessed as druggable using the relaxed criteria10


		
PDB Chain Protein Name Druggable Relaxed Druggable Strict Details
1M4R_A Interleukin-22 Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.5 67.3 31.3 Yes No
2 empty 2.34 64.2 18 No No
3 empty 1.83 73 14.2 No No
4 empty 2.15 59.8 13.8 No No
5 empty 1.99 68.9 12.1 No No
6 empty 2.22 64.4 9.7 No No
7 empty 2.27 68.1 11.5 No No
8 empty 2.26 76.1 6.3 No No
9 empty 2.6 52.4 9.2 No No
10 empty 2.71 64.4 8.3 No No
1YKB_F Interleukin-22 Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.34 64.7 26.2 Yes No
2 empty 2.24 65.5 16.2 No No
3 empty 1.93 65.9 14.1 No No
4 bound 2.32 68.6 11.9 No No
5 empty 2.46 65.3 10.7 No No
6 empty 2.81 74.4 8.1 No No
7 empty 2.29 74.2 6.7 No No
8 empty 1.91 56.4 9.5 No No
9 empty 2.13 77 7.1 No No
10 empty 2.38 76.5 6.2 No No
1YKB_A Interleukin-22 Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.57 67.6 29.5 Yes No
2 empty 2.1 65.9 22.8 No No
3 empty 1.96 64.6 15.6 No No
4 bound 2.27 68.9 11.5 No No
5 empty 2.29 66.9 17.1 No No
6 empty 2.45 67.9 9.1 No No
7 empty 2.36 69.5 10.1 No No
8 empty 2.89 67.8 15.9 No No
9 empty 2.6 68.3 10.2 No No
10 empty 2.32 77.8 5.9 No No
1YKB_D Interleukin-22 Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.19 65.3 27.4 Yes No
2 empty 2.02 67.4 19.5 No No
3 empty 1.85 69 14.4 No No
4 empty 2.21 66.7 13.7 No No
5 bound 2.33 69 11.2 No No
6 empty 2.27 77.3 6.2 No No
7 empty 2.25 73.1 7.9 No No
8 empty 2.43 61.7 7.2 No No
9 empty 3.28 67.3 7.9 No No
10 empty .9 99.2 0 Yes No
3G9V_D Interleukin-22 Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.2 66.7 28.7 Yes No
2 empty 2.3 65.2 18.4 No No
3 empty 2.03 71.9 11.5 No No
4 empty 2.5 69.2 10.1 No No
5 empty 2.14 62.7 10.6 No No
6 empty 2.46 68 10.5 No No
7 empty 2.25 67 9.5 No No
8 empty 2.59 56.6 10.1 No No
9 empty 2.43 71.1 7.3 No No
10 empty 2.12 75 7.8 No No
1YKB_C Interleukin-22 No No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.05 67.1 18.3 No No
2 empty 2.8 67.8 20.8 No No
3 bound 2.23 66 17.6 No No
4 empty 1.95 65 14.2 No No
5 empty 2.04 72.7 12.6 No No
6 empty 2.56 60.4 12.2 No No
7 empty 3 69.5 10.6 No No
8 empty 2.17 67.7 6.9 No No
9 empty 2.79 54.1 8.5 No No
10 empty 2.26 70.6 7.2 No No
3DGC_M Interleukin-22 Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.39 68.2 27.6 Yes No
2 empty 2.05 62.1 16 No No
3 empty 2.06 61.7 17.6 No No
4 empty 2.35 62.4 10.1 No No
5 empty 2.24 72.9 9.2 No No
6 empty 2.64 67.8 8.1 No No
7 empty 2.06 64.6 12.5 No No
8 empty 2.1 72.3 7.4 No No
9 empty 2.5 66.7 9.4 No No
10 empty 2.8 80 0 No No
3Q1S_I Interleukin-22 Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 2.14 67.2 38.4 Yes Yes
2 empty 2.5 63.7 13.9 No No
3 empty 2.32 57.7 13.8 No No
4 empty 2.29 58.6 14.8 No No
5 empty 2.55 69.3 12.5 No No
6 empty 1.24 100 0 Yes No
7 empty 2.64 65.8 7.6 No No
8 empty 2.44 69 8.6 No No
9 empty 2.32 74.2 7.5 No No
10 empty 2 60 10.4 No No
1YKB_E Interleukin-22 No No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.05 65.6 19.6 No No
2 empty 2.62 66.7 19.2 No No
3 empty 2.14 69.8 14.4 No No
4 empty 2.18 60.2 14.8 No No
5 empty 2.03 67 10.9 No No
6 bound 2.48 69.3 12.1 No No
7 empty 2.99 68.5 10.9 No No
8 empty 2.69 66.7 7.6 No No
9 empty 1.89 69.2 8.6 No No
10 empty 2.28 67.6 8.8 No No
3DGC_L Interleukin-22 Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.48 68.1 31 Yes No
2 empty 2.29 64.6 13.7 No No
3 empty 2.89 71.1 17.5 No No
4 empty 2.37 67.4 12.2 No No
5 empty 2.27 65 11.6 No No
6 empty 2.39 64.9 9.2 No No
7 empty 2.75 61.1 11.9 No No
8 empty 2.41 64.7 10.9 No No
9 empty 1.54 67.2 10.2 No No
10 empty 2.02 65 7.9 No No
1M4R_B Interleukin-22 No No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.1 61.5 13.3 No No
2 empty 2.44 65.4 12.3 No No
3 empty 1.83 63.7 12.5 No No
4 empty 1.86 68.8 9.9 No No
5 empty 1.53 79.1 9.7 No No
6 empty 2.43 65.2 9.8 No No
7 empty 2.42 68.8 9 No No
8 empty 2.7 58.3 13.6 No No
9 empty 2.31 69.8 8.3 No No
10 empty 2.22 68.6 10.4 No No
3DLQ_I Interleukin-22 Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.27 65.8 34.3 Yes No
2 empty 2.42 65.9 13.1 No No
3 empty 2.53 60.3 17.1 No No
4 empty 2.38 69.8 11.9 No No
5 empty 2.42 67.5 12.3 No No
6 empty 2.2 70.7 14.5 No No
7 empty 2.77 70.2 13.6 No No
8 empty 2.67 64.7 9 No No
9 empty 2.78 64.4 9.1 No No
10 empty 2.25 66.7 10.8 No No
3G9V_B Interleukin-22 Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.32 65.4 34.2 Yes No
2 empty 2.64 65.4 18.1 No No
3 empty 2.44 59 13.9 No No
4 empty 2.41 69.9 13.4 No No
5 empty 2.38 72.6 11 No No
6 empty 2.27 70.9 9.8 No No
7 empty 2.35 67.3 10.6 No No
8 empty 2.52 57.3 11.7 No No
9 empty 2.65 56.6 8.9 No No
10 empty 2.23 78 7.2 No No
1YKB_B Interleukin-22 No No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.03 66.5 20.6 No No
2 empty 2.54 62.3 25.1 No No
3 empty 2.65 68.8 13.4 No No
4 empty 1.93 63.3 15 No No
5 bound 2.36 77.2 9.8 No No
6 empty 2.09 69.6 11.3 No No
7 empty 2.01 72.9 8 No No
8 empty 2.85 70.8 10.4 No No
9 empty 2.67 66.4 8.4 No No
10 empty 2.55 67.8 8.4 No No

Domain-based assessment (last updated 30/07/2012)


Domains assessed12
Domains assessed as druggable using the strict criteria0
Domains assessed as druggable using the relaxed criteria9

PDB (Domain) Protein Name Domain Resolution Ligands Druggable Relaxed Druggable Strict
1M4R_B (4215817) Interleukin-22 4-helical cytokines, 4-helical cytokines, Interferons/interleukin-10 (IL-10) (Homo Multimer) 2Å Yes No
1M4R_A (84799) Interleukin-22 4-helical cytokines, 4-helical cytokines, Interferons/interleukin-10 (IL-10) 2Å Yes No
1M4R_A (4215817) Interleukin-22 4-helical cytokines, 4-helical cytokines, Interferons/interleukin-10 (IL-10) (Homo Multimer) 2Å Yes No
1M4R_B (84800) Interleukin-22 4-helical cytokines, 4-helical cytokines, Interferons/interleukin-10 (IL-10) 2Å No No
1YKB_F (123508) Interleukin-22 4-helical cytokines, 4-helical cytokines, Interferons/interleukin-10 (IL-10) 2.5Å Yes No
1YKB_D (123506) Interleukin-22 4-helical cytokines, 4-helical cytokines, Interferons/interleukin-10 (IL-10) 2.5Å Yes No
1YKB_C (123505) Interleukin-22 4-helical cytokines, 4-helical cytokines, Interferons/interleukin-10 (IL-10) 2.5Å Yes No
1YKB_B (123504) Interleukin-22 4-helical cytokines, 4-helical cytokines, Interferons/interleukin-10 (IL-10) 2.5Å No No
1YKB_A (123503) Interleukin-22 4-helical cytokines, 4-helical cytokines, Interferons/interleukin-10 (IL-10) 2.5Å Yes No
1YKB_E (123507) Interleukin-22 4-helical cytokines, 4-helical cytokines, Interferons/interleukin-10 (IL-10) 2.5Å No No
3DGC_L (3360283) Interleukin-22 4-helical cytokines, 4-helical cytokines, UNMATCHED 2.5Å Yes No
3DLQ_I (157802) Interleukin-22 4-helical cytokines, 4-helical cytokines, Interferons/interleukin-10 (IL-10) 1.9Å Yes No
3G9V_B (3430031) Interleukin-22 4-helical cytokines, 4-helical cytokines, UNMATCHED 2.75Å Yes No
Ligand-based Druggability Score: -3
Ligand-based Druggability Score Percentile: 59%
Ligand-based Druggability Help: Help




		
Number of proteins in the network : 13346


IL22 is involved in 3 interactions in the network.


Druggability
Overall Druggability Percentile: 80.45
Druggability for Cancer Therapeutics: 41.87
Druggability for Other Therapeutics: 91.82
Cancer-Associated
Cancer-associated percentile : 8.73
Network Articulation Point
Is IL22 critical for communication in the network?


Detailed Graph Legend:Help