Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
Chemistry
Ligand Efficiency Plot
Pathways
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
RNAi
Mutations
Germline Genetics

IL22 (Q9GZX6) - Overview - Molecular Target Synopsis

Protein


IL22, Interleukin-22
UniProt Q9GZX6

Also Known as IL22_HUMAN, IL22, ILTIF, ZCYTO18

Cytokine that contributes to the inflammatory response in vivo.

3Q1S
HIV-1 NEUTRALIZING ANTIBODY Z13E1 IN COMPLEX WITH EPITOPE DISPLAY PROTEIN
RCSB/PDB
Inspect Structure
See all 3D Structures for IL22

Isoforms / Transcripts (Protein Coding)


Protein Length Ensembl Gene Ensembl Transcript Ensembl Protein Uniprot Isoform
179ENSG00000127318ENST00000328087, ENST00000538666ENSP00000329384, ENSP00000442424Q9GZX6-1

Sub-cellular localization


UniProt: IL22 is active in the following subcellular-locations: secreted.
GO terms: IL22 is active in the following subcellular-locations: extracellular region, extracellular space.



UniProt
GO terms

Gene Copy Number Variation


In COSMIC - Cell Lines Project IL22 has gain in 4 cell-lines, loss in 2 cell-lines and no signal in 998 cell-lines. (see details)

Gene Expression


In NCI60, the highest expressing cell lines are: KM12, TK_10, 786_0

In Array Express (RNA-seq of 675 commonly used human cancer cell lines), the highest expressing cell lines are: Hs 746T, NCI-H209, LN-18

In Array Express (RNA-seq of long poly adenylated RNA and long non poly adenylated RNA from ENCODE cell lines), the highest expressing cell lines are: SK-N-SH, NHLF, HSMM

(see details)

3D Structures


For IL22 there are:
6 structures (14 chains) solved
1 are solved in complex with at least one small molecule ligand



(see details)
Molecular Target 3D Synopsis