Molecular Target Synopsis
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MCOLN1 (Q9GZU1) - Druggability - Molecular Target Synopsis

Chain-based assessment (last updated 03/09/2019)
Structural Druggability Help: Help

Chain-based assessment (last updated 03/09/2019)


Chains assessed22
Chains with at least one site assessed as druggable using the strict criteria16
Chains with at least one site assessed as druggable using the relaxed criteria21


		
PDB Chain Protein Name Druggable Relaxed Druggable Strict Details
5WJ9_D Mucolipin-1 Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.02 69.7 43 Yes Yes
2 empty 1.99 52.5 27.4 No No
3 empty 1.92 74.5 19.6 No No
4 empty 2.35 65.5 29.8 No No
5 empty 1.85 61.6 18.7 No No
6 empty 2.08 67.1 19.8 No No
7 empty 2.29 65.7 25.2 No No
8 empty 2.23 68.6 19.9 No No
9 bound .95 64.6 14.6 No No
10 empty 2.44 71.8 14.4 No No
6E7Y_D Mucolipin-1 Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.28 70.5 54 Yes Yes
2 bound 1.76 67.6 43.1 No No
3 empty 1.93 64.9 19.8 No No
4 empty 2.42 75.3 18.6 No No
5 empty 1.53 37.8 18.4 No No
6 empty .87 69.7 13 No No
7 empty 2.19 60.6 18.5 No No
8 empty .98 71.3 13.3 No No
9 empty 2.12 66.7 15.8 No No
10 empty 1.91 59.2 21.1 No No
5TJC_A Mucolipin-1 Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.02 62.1 34.2 Yes No
2 empty 1.77 64.1 20.2 No No
3 empty 2.41 65.3 22.4 No No
4 empty 2.09 64.3 27.6 No No
5 empty 2.43 64.8 21.3 No No
6 empty 2.26 68.8 12.5 No No
7 empty 2.39 60.9 13.1 No No
8 empty 2.04 59.4 11.2 No No
9 empty 2.37 62.1 14.6 No No
10 empty 1.73 80.5 10 No No
5WJ9_C Mucolipin-1 Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 1.89 70.6 43.4 Yes Yes
2 empty 1.99 52.1 26.2 No No
3 empty 1.85 62.9 19.7 No No
4 empty 1.94 67.3 22.9 No No
5 empty 2.31 63.2 30.1 No No
6 empty 2.05 67.7 19.4 No No
7 empty 2.08 66.8 21.4 No No
8 empty 2.28 67.1 25.3 No No
9 bound .95 63.2 16 No No
10 empty 2.64 66.5 18.9 No No
6E7P_B Mucolipin-1 Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 2.16 70.4 38 Yes Yes
2 empty 2.3 72.5 41.3 No No
3 empty 1.97 63.4 36.1 No No
4 empty 1.91 64.3 23.8 No No
5 empty 2.21 83.1 17.2 No No
6 empty 2.28 66.7 30.1 No No
7 empty 2.25 55.1 20.8 No No
8 empty 1.56 36.1 19.6 No No
9 empty 1.19 68.3 19.4 No No
10 empty 2.11 65.1 16.7 No No
6E7Y_C Mucolipin-1 Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.31 70.2 54.9 Yes Yes
2 bound 1.74 68.2 42.6 No No
3 empty 1.93 64.5 20 No No
4 empty 2.42 73.5 20.4 No No
5 empty 1.53 38.6 18.9 No No
6 empty .87 71.7 12 No No
7 empty 2.19 62.4 17.4 No No
8 empty .98 69.9 14.5 No No
9 empty 1.95 59.6 21.1 No No
10 empty 2.12 68.8 13.1 No No
6E7P_A Mucolipin-1 Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 2.17 70.1 40.8 Yes Yes
2 empty 2.33 72.4 41.5 No No
3 empty 1.97 63.8 34.1 No No
4 empty 1.91 64.8 24.2 No No
5 empty 2.21 82.8 15.8 No No
6 empty 2.3 66.6 25.6 No No
7 empty 2.25 53.6 18.7 No No
8 empty 1.59 34.1 18.8 No No
9 empty 1.19 66.6 19 No No
10 empty 2.12 62.2 20.1 No No
5WJ9_B Mucolipin-1 Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 1.9 68.8 42.9 Yes Yes
2 empty 1.99 51.6 30.2 No No
3 empty 2.17 73.8 25.3 No No
4 empty 1.86 63.1 18 No No
5 empty 2.04 67.9 19.1 No No
6 empty 2.43 64.7 31.2 No No
7 empty 1.79 69.3 18 No No
8 bound .95 63.8 17.1 No No
9 empty 2.29 67.3 29.8 No No
10 empty 1.92 61.7 17.7 No No
5WJ5_B Mucolipin-1 Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.04 73.2 29.8 Yes Yes
2 empty 1.73 68.1 28.9 No No
3 empty 1.66 58.8 32 No No
4 empty 2.25 65.7 34.6 No No
5 empty 2.19 57.3 30.7 No No
6 empty 2.03 63.2 32.9 No No
7 empty 1.86 64 18.7 No No
8 empty 1.47 39.5 19.5 No No
9 empty 1.96 62.2 29.6 No No
10 empty 1.15 62.3 19.5 No No
6E7Z_C Mucolipin-1 Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 2 71.6 42.3 Yes Yes
2 empty 1.78 63.9 29.9 No No
3 empty 1.92 68.2 20.1 No No
4 empty 1.88 54 23.3 No No
5 empty 2.3 86.1 20.9 Yes No
6 empty 2.41 68.1 24.9 No No
7 empty 2.14 71 18.5 No No
8 bound 1.08 71.7 17.7 No No
9 empty 2.2 63 16.5 No No
10 empty 1.85 69.7 13.3 No No
6E7Z_A Mucolipin-1 Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 2.01 71.6 43.3 Yes Yes
2 empty 1.78 65.1 33.1 No No
3 empty 1.96 68.3 20.4 No No
4 empty 1.87 53.7 23.8 No No
5 empty 2.29 86.1 22.6 Yes No
6 empty 2.47 70.1 30.7 No No
7 empty 2.14 71.4 21.1 No No
8 bound 1.09 68.3 18.1 No No
9 empty 2.37 59.7 16.3 No No
10 empty 1.86 69.4 19.5 No No
6E7P_C Mucolipin-1 Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 2.18 69.1 40.2 Yes Yes
2 empty 2.46 73.7 41.6 No No
3 empty 1.97 63.3 36.4 No No
4 empty 1.94 64.2 24 No No
5 empty 2.28 65.7 19.6 No No
6 empty 2.21 82.5 17.3 No No
7 empty 2.2 55 21.4 No No
8 empty 1.56 37.2 17.9 No No
9 empty 1.19 69.8 19.5 No No
10 empty 2.09 65.7 17.2 No No
6E7Z_D Mucolipin-1 Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 2.01 71.3 44.4 Yes Yes
2 empty 1.8 66.1 31.4 No No
3 empty 1.96 68.7 22.3 No No
4 empty 2.23 84.4 22.8 Yes No
5 empty 2.47 67.2 34.7 No No
6 empty 1.75 51.4 24.6 No No
7 empty 2.15 72.7 18.3 No No
8 bound 1.09 69.1 17.7 No No
9 empty 2.3 58.9 17.3 No No
10 empty 1.85 69.4 16.8 No No
6E7Y_A Mucolipin-1 Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.31 69.8 55.4 Yes Yes
2 bound 1.75 67.9 43.1 No No
3 empty 1.92 65.2 20.3 No No
4 empty 2.43 74.1 16.6 No No
5 empty 1.53 35.8 19.2 No No
6 empty .87 67.6 14.5 No No
7 empty 2.19 61.5 18.5 No No
8 empty .97 71.4 14.3 No No
9 empty 1.96 60.5 21.6 No No
10 empty 2.12 68.5 17.2 No No
5TJA_A Mucolipin-1 Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.19 63.2 33 Yes No
2 empty 1.83 60 21.3 No No
3 empty 1.99 67.5 24.1 No No
4 empty 2.16 69.7 18.6 No No
5 empty 2.43 58.3 15.2 No No
6 empty 2.12 66 13.8 No No
7 empty 2.11 57.4 14.7 No No
8 empty 1.97 62.5 10 No No
9 empty 2.55 70.3 10.3 No No
10 empty 2.42 57.1 10.9 No No
6E7Y_B Mucolipin-1 No No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 No No
2 No No
3 No No
4 No No
5 No No
6 No No
7 No No
8 No No
9 No No
10 No No
5WJ9_A Mucolipin-1 Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.15 70.4 43.6 Yes Yes
2 empty 1.99 51.7 30.9 No No
3 empty 1.79 62.8 19.3 No No
4 empty 2.07 68.7 17.8 No No
5 empty 2.17 75.2 17.1 No No
6 empty 2.34 64.8 27.2 No No
7 bound .95 64.9 16.4 No No
8 empty 2.6 66.5 19.7 No No
9 empty 2.25 66 20 No No
10 empty 2.17 84.2 20.6 No No
5TJB_A Mucolipin-1 Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.37 64 41.4 Yes No
2 empty 2 72.1 15.3 No No
3 empty 1.98 74.6 9.9 No No
4 empty 2.61 62.5 15.4 No No
5 empty 2.35 60.8 13.9 No No
6 empty 2.23 53.5 12 No No
7 empty 2.39 66.5 8 No No
8 empty 2.59 67.1 8.3 No No
9 empty 2.77 66 7.3 No No
10 empty 2.26 66.5 6.7 No No
6E7Z_B Mucolipin-1 Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 2.01 72.5 40.5 Yes Yes
2 empty 2.33 70.1 39 No No
3 empty 1.97 67.4 20.7 No No
4 empty 1.88 53.1 26 No No
5 empty 2.44 69.4 32.1 No No
6 empty 2.15 69.9 24.4 No No
7 bound 1.09 69.6 18.1 No No
8 empty 2.21 61.9 15.8 No No
9 empty 1.86 68.6 18.9 No No
10 empty 2.05 63.2 12.8 No No
5WJ5_A Mucolipin-1 Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 1.75 65.8 44.5 Yes No
2 empty 2.18 69.3 44.2 No No
3 empty 2.05 59.3 42.1 No No
4 empty 1.86 64.2 18.8 No No
5 empty 1.51 39.7 19 No No
6 empty 2.17 70 24.7 No No
7 empty 1.85 59.9 27.2 No No
8 empty 1.12 61.7 19.9 No No
9 empty 1.93 73.8 7.8 No No
10 empty 1.76 63.2 10.7 No No
5WJ5_D Mucolipin-1 Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.13 70.3 42.7 Yes Yes
2 empty 1.89 64.9 43.6 No No
3 empty 2.28 56.4 30.8 No No
4 empty 1.99 62.2 31 No No
5 empty 1.91 60.8 20.7 No No
6 empty 1.5 39.6 18.4 No No
7 empty 1.12 64.5 17.8 No No
8 empty 2.06 53.1 15.9 No No
9 empty 2.38 82.7 13.1 No No
10 empty 2.31 63.6 14.7 No No
5WJ5_C Mucolipin-1 Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 1.69 65.5 43.1 Yes No
2 empty 1.89 73.5 34.7 No No
3 empty 2.23 63 33.9 No No
4 empty 2.07 58.4 29 No No
5 empty 2.05 62.1 32.9 No No
6 empty 1.86 63 18.3 No No
7 empty 1.62 45.8 21.2 No No
8 empty 1.15 65.2 17.6 No No
9 empty 2.16 54.2 17.5 No No
10 empty 2.31 75.6 12.5 No No
Ligand-based Druggability Score: -3
Ligand-based Druggability Score Percentile: 59%
Ligand-based Druggability Help: Help




		
Number of proteins in the network : 13346


MCOLN1 is involved in 3 interactions in the network.


Druggability
Overall Druggability Percentile: 41.87
Druggability for Cancer Therapeutics: 30.45
Druggability for Other Therapeutics: 23.69
Cancer-Associated
Cancer-associated percentile : 44.59
Network Articulation Point
Is MCOLN1 critical for communication in the network?


Detailed Graph Legend:Help