Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
Chemistry
Ligand Efficiency Plot
Pathways
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
RNAi
Mutations
Germline Genetics

KIN14E (Q9FHN8) - Overview - Molecular Target Synopsis

Protein


KIN14E, Kinesin-like protein KIN-14E
UniProt Q9FHN8

Also Known as KN14E_ARATH, KIN14E, KCBP, ZWI

Minus-end microtubule-dependent motor protein involved in the regulation of cell division and trichome morphogenesis through microtubules bundling. Possesses basal and microtubule-stimulated ATPase activities. Acts as a hub that brings together microtubules and actin filaments to modulate the cytoskeleton during trichome formation and morphogenesis (PubMed:26287478). Could be involved in the negative regulation of root growth (PubMed:25262228). Homodimer (via C-terminus) (PubMed:23805258). Binds microtubules via its N-terminus containing the MyTH4 domain and binds F-actin via its FERM domain (PubMed:26287478). Interacts with KIPK1 (PubMed:10788494, PubMed:25262228). Interacts with KIPK2 (PubMed:25262228). Interacts with AN (PubMed:11889034). Interacts with AIR9 (PubMed:25908862). Interacts (via C-terminus) with KIC, CAM2, CAM4 and CAM6. KIC and calmodulin show competitive binding to KCBP. Binding to calmodulin inhibits microtubule binding activity. Binding to KIC inhibits microtubule binding activity and microtubule-stimulated ATPase activity.

4FRZ
ARABIDOPSIS KCBP MOTOR DOMAIN DIMERIZED VIA REGULATORY DOMAIN
RCSB/PDB
Inspect Structure
See all 3D Structures for KIN14E

Isoforms / Transcripts (Protein Coding)


Protein Length Ensembl Gene Ensembl Transcript Ensembl Protein Uniprot Isoform
1260Q9FHN8-1
1259Q9FHN8-2

Sub-cellular localization


UniProt: KIN14E is active in the following subcellular-locations: cell cortex, cytoplasm, cytoskeleton, phragmoplast, spindle.
GO terms: KIN14E is active in the following subcellular-locations: cortical microtubule, cytoskeleton, kinesin complex, microtubule, mitotic spindle, phragmoplast.



UniProt
GO terms

Gene Copy Number Variation


In COSMIC - Cell Lines Project KIN14E has gain in 0 cell-lines, loss in 0 cell-lines and no signal in 0 cell-lines. (see details)

3D Structures


For KIN14E there are:
2 structures (3 chains) solved
2 are solved in complex with at least one small molecule ligand



(see details)
Molecular Target 3D Synopsis

Screening and Chemistry


KIN14E has been screened with compounds ( bioactivities). (see details)