Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
Chemistry
Ligand Efficiency Plot
Pathways
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
RNAi
Mutations
Germline Genetics

OPR3 (Q9FEW9) - Overview - Molecular Target Synopsis

Protein


OPR3, 12-oxophytodienoate reductase 3
Enzyme Classification 1.3.1.42
UniProt Q9FEW9

Also Known as OPR3_SOLLC, OPR3

Specifically cleaves olefinic bonds in cyclic enones. Involved in the biosynthesis of jasmonic acid (JA) and perhaps in biosynthesis or metabolism of other oxylipin signaling moleclules. It is required for the spatial and temporal regulation of JA levels during dehiscence of anthers, promoting the stomium degeneration program (By similarity). In vitro, reduces 9S,13S-12-oxophytodienoic acid (9S,13S-OPDA) and 9R,13R-OPDA to 9S,13S-OPC-8:0 and 9R,13R-OPC-8:0, respectively.

3HGS
CRYSTAL STRUCTURE OF TOMATO OPR3 IN COMPLEX WITH PHB
RCSB/PDB
Inspect Structure
See all 3D Structures for OPR3

Isoforms / Transcripts (Protein Coding)


Protein Length Ensembl Gene Ensembl Transcript Ensembl Protein Uniprot Isoform
396Q9FEW9-1

Sub-cellular localization


UniProt: OPR3 is active in the following subcellular-locations: peroxisome.
GO terms: OPR3 is active in the following subcellular-locations: peroxisome.



UniProt
GO terms

Gene Copy Number Variation


In COSMIC - Cell Lines Project OPR3 has gain in 0 cell-lines, loss in 0 cell-lines and no signal in 0 cell-lines. (see details)

3D Structures


For OPR3 there are:
5 structures (10 chains) solved
5 are solved in complex with at least one small molecule ligand
5 are solved with an approved drug

OPR3 is solved in complex with the approved drug(s):

FMN/RIBOFLAVIN 5'-PHOSPHATE (2HS6_A, 2HS6_B, 2HS8_A, 2HS8_B, 2HSA_A, 2HSA_B, 3HGO_A, 3HGO_B, 3HGS_A, 3HGS_B).

(see details)
Molecular Target 3D Synopsis