Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
Chemistry
Ligand Efficiency Plot
Pathways
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
RNAi
Mutations
Germline Genetics

Apbb2 (Q9DBR4) - Overview - Molecular Target Synopsis

Protein


Apbb2, Amyloid-beta A4 precursor protein-binding family B member 2
UniProt Q9DBR4

Also Known as APBB2_MOUSE, Apbb2

May modulate the internalization of amyloid-beta precursor protein. Binds to the intracellular domain of the amyloid-beta precursor protein.

2ROZ
STRUCTURE OF THE C-TERMINAL PID DOMAIN OF FE65L1 COMPLEXED WITH THE CYTOPLASMIC TAIL OF APP REVEALS A NOVEL PEPTIDE BINDING MODE
RCSB/PDB
Inspect Structure
See all 3D Structures for Apbb2

Isoforms / Transcripts (Protein Coding)


Protein Length Ensembl Gene Ensembl Transcript Ensembl Protein Uniprot Isoform
760Q9DBR4-1
739Q9DBR4-2
737Q9DBR4-3

Sub-cellular localization


GO terms: Apbb2 is active in the following subcellular-locations: cytoplasm, nucleus.



UniProt
GO terms

Gene Copy Number Variation


In COSMIC - Cell Lines Project Apbb2 has gain in 0 cell-lines, loss in 0 cell-lines and no signal in 0 cell-lines. (see details)

3D Structures


For Apbb2 there are:
5 structures (5 chains) solved
0 are solved in complex with at least one small molecule ligand



(see details)
Molecular Target 3D Synopsis