Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
Chemistry
Ligand Efficiency Plot
Pathways
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
RNAi
Mutations
Germline Genetics

Msra (Q9D6Y7) - Overview - Molecular Target Synopsis

Protein


Msra, Mitochondrial peptide methionine sulfoxide reductase
Enzyme Classification 1.8.4.11
UniProt Q9D6Y7

Also Known as MSRA_MOUSE, Msra

Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine.

2L90
SOLUTION STRUCTURE OF MURINE MYRISTOYLATED MSRA
RCSB/PDB
Inspect Structure
See all 3D Structures for Msra

Isoforms / Transcripts (Protein Coding)


Protein Length Ensembl Gene Ensembl Transcript Ensembl Protein Uniprot Isoform
233Q9D6Y7-1
213Q9D6Y7-2
193Q9D6Y7-3
191Q9D6Y7-4

Sub-cellular localization


UniProt: Msra is active in the following subcellular-locations: cytoplasm, membrane, mitochondrion, nucleus.
GO terms: Msra is active in the following subcellular-locations: actin cytoskeleton, cytoplasm, cytosol, membrane, mitochondrion, nucleoplasm.



UniProt
GO terms

Gene Copy Number Variation


In COSMIC - Cell Lines Project Msra has gain in 0 cell-lines, loss in 0 cell-lines and no signal in 0 cell-lines. (see details)

3D Structures


For Msra there are:
1 structures (1 chains) solved
0 are solved in complex with at least one small molecule ligand



(see details)
Molecular Target 3D Synopsis

Screening and Chemistry


Msra has been screened with compounds ( bioactivities). (see details)