STRADB (Q9C0K7) - Overview - Molecular Target Synopsis
STRADB, STE20-related kinase adapter protein beta
Also Known as STRAB_HUMAN, STRADB, ALS2CR2, ILPIP
Pseudokinase which, in complex with CAB39/MO25 (CAB39/MO25alpha or CAB39L/MO25beta), binds to and activates STK11/LKB1. Adopts a closed conformation typical of active protein kinases and binds STK11/LKB1 as a pseudosubstrate, promoting conformational change of STK11/LKB1 in an active conformation. Component of a trimeric complex composed of STK11/LKB1, STRAD (STRADA or STRADB) and CAB39/MO25 (CAB39/MO25alpha or CAB39L/MO25beta): the complex tethers STK11/LKB1 in the cytoplasm and stimulates its catalytic activity. Interacts with BIRC4/XIAP. These two proteins are likely to coexist in a complex with TAK1, TRAF6, TAB1 and TAB2.
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UniProt: STRADB is active in the following subcellular-locations: cytoplasm, nucleus.
GO terms: STRADB is active in the following subcellular-locations: aggresome, cytoplasm, cytosol, nucleus.