Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
Chemistry
Ligand Efficiency Plot
Pathways
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
RNAi
Mutations
Germline Genetics

ACTR3C (Q9C0K3) - Overview - Molecular Target Synopsis

Protein


ACTR3C, Actin-related protein 3C
UniProt Q9C0K3

Also Known as ARP3C_HUMAN, ACTR3C, ARP11

May play a role in the suppression of metastatic potential in lung adenoma carcinoma cells.

Isoforms / Transcripts (Protein Coding)


Sub-cellular localization


GO terms: ACTR3C is active in the following subcellular-locations: Arp2/3 protein complex, extracellular exosome.



UniProt
GO terms

Gene Copy Number Variation


In COSMIC - Cell Lines Project ACTR3C has gain in 3 cell-lines, loss in 4 cell-lines and no signal in 998 cell-lines. (see details)

Gene Expression


In NCI60, the highest expressing cell lines are:

In Array Express (RNA-seq of 675 commonly used human cancer cell lines), the highest expressing cell lines are: HCC1011, ACHN, LCLC-103H

In Array Express (RNA-seq of long poly adenylated RNA and long non poly adenylated RNA from ENCODE cell lines), the highest expressing cell lines are: SK-N-SH, NHLF, HSMM

(see details)

3D Structures


At greater than 75% identity similarity to ACTR3C there are:
20 structures (22 chains) solved
13 are solved in complex with at least one small molecule ligand



(see details)
Molecular Target 3D Synopsis

Screening and Chemistry


ACTR3C has been screened with compounds ( bioactivities). (see details)