Molecular Target Synopsis
Domains and Structures
Drugs and Clinical Candidates
Ligand Efficiency Plot
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
Germline Genetics

ACTR3C (Q9C0K3) - Overview - Molecular Target Synopsis


ACTR3C, Actin-related protein 3C
UniProt Q9C0K3

Also Known as ARP3C_HUMAN, ACTR3C, ARP11

May play a role in the suppression of metastatic potential in lung adenoma carcinoma cells.

Isoforms / Transcripts (Protein Coding)

Sub-cellular localization

GO terms: ACTR3C is active in the following subcellular-locations: Arp2/3 protein complex, extracellular exosome.

GO terms

Gene Copy Number Variation

In COSMIC - Cell Lines Project ACTR3C has gain in 3 cell-lines, loss in 4 cell-lines and no signal in 998 cell-lines. (see details)

Gene Expression

In NCI60, the highest expressing cell lines are:

In Array Express (RNA-seq of 675 commonly used human cancer cell lines), the highest expressing cell lines are: HCC1011, ACHN, LCLC-103H

In Array Express (RNA-seq of long poly adenylated RNA and long non poly adenylated RNA from ENCODE cell lines), the highest expressing cell lines are: SK-N-SH, NHLF, HSMM

(see details)

3D Structures

At greater than 75% identity similarity to ACTR3C there are:
20 structures (22 chains) solved
13 are solved in complex with at least one small molecule ligand

(see details)
Molecular Target 3D Synopsis

Screening and Chemistry

ACTR3C has been screened with compounds ( bioactivities). (see details)